Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas

BMC Cancer

Research Article

Haralabos P Kalofonos¹  Vassiliki T Labropoulou¹  Katalin Dobra²  Panagiota Ravazoula³  Eleni Likaki-Karatza⁴  Achilleas D Theocharis⁵  Nikos K Karamanos⁵  Spyros S Skandalis⁶ 

[1] Clinical Oncology Laboratory, Division of Oncology, Department of Medicine, University Hospital of Patras, Patras Medical School, 26504, Rio, Greece;Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, F-46 Huddinge University Hospital, SE-14186, Stockholm, Sweden;Department of Pathology, University Hospital of Patras, 26504, Rio, Greece;Department of Radiology, University Hospital of Patras, 26504, Rio, Greece;Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504, Rio, Greece;Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504, Rio, Greece;Ludwig Institute for Cancer Research, Uppsala Branch, Box 595, 75124, Uppsala, Sweden;

关键词: proteoglycans;    versican;    decorin;    mammographic density;    malignant-appearing microcalcifications;    non-palpable breast carcinomas;   

DOI  :  10.1186/1471-2407-11-314

 received in 2010-09-24, accepted in 2011-07-26,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequently over-expressed in various malignancies and are differently involved in the progression of cancer. In the present study, we have evaluated the expression of versican and decorin in non-palpable breast carcinomas and their association with high risk mammographic findings and tumor characteristics.MethodsThree hundred and ten patients with non-palpable suspicious breast lesions, detected during screening mammography, were studied. Histological examination was carried out and the expression of decorin, versican, estrogen receptor α (ERα), progesterone receptor (PR) and c-erbB2 (HER-2/neu) was assessed by immunohistochemistry.ResultsHistological examination showed 83 out of 310 (26.8%) carcinomas of various subtypes. Immunohistochemistry was carried out in 62/83 carcinomas. Decorin was accumulated in breast tissues with MD and MAMCs independently of the presence of malignancy. In contrast, versican was significantly increased only in carcinomas with MAMCs (median ± SE: 42.0 ± 9.1) and MD (22.5 ± 10.1) as compared to normal breast tissue with MAMCs (14.0 ± 5.8), MD (11.0 ± 4.4) and normal breast tissue without mammographic findings (10.0 ± 2.0). Elevated levels of versican were correlated with higher tumor grade and invasiveness in carcinomas with MD and MAMCs, whereas increased amounts of decorin were associated with in situ carcinomas in MAMCs. Stromal deposition of both proteoglycans was related to higher expression of ERα and PR in tumor cells only in MAMCs.ConclusionsThe specific accumulation of versican in breast tissue with high MD and MAMCs only in the presence of malignant transformation and its association with the aggressiveness of the tumor suggests its possible use as molecular marker in non-palpable breast carcinomas.

【 授权许可】

Unknown   
© Skandalis et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.