Wolbachia infections that reduce immature insect survival: Predicted impacts on population replacement

BMC Evolutionary Biology

Research Article

Philip H Crowley¹  Yunxin Huang¹  Stephen L Dobson²  Philip R Crain²  Eunho Suh²  James W Mains² 

[1] Department of Biology, Center for Ecology, Evolution and Behavior, University of Kentucky, 40502-0225, Lexington, KY, USA;Department of Entomology, College of Agriculture, University of Kentucky, 40546-0091, Lexington, KY, USA;

关键词: Larval Survival;    Maternal Inheritance;    Infection Frequency;    Cytoplasmic Incompatibility;    Wolbachia Infection;   

DOI  :  10.1186/1471-2148-11-290

 received in 2011-05-26, accepted in 2011-10-05,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe evolutionary success of Wolbachia bacteria, infections of which are widespread in invertebrates, is largely attributed to an ability to manipulate host reproduction without imposing substantial fitness costs. Here, we describe a stage-structured model with deterministic immature lifestages and a stochastic adult female lifestage. Simulations were conducted to better understand Wolbachia invasions into uninfected host populations. The model includes conventional Wolbachia parameters (the level of cytoplasmic incompatibility, maternal inheritance, the relative fecundity of infected females, and the initial Wolbachia infection frequency) and a new parameter termed relative larval viability (RLV), which is the survival of infected larvae relative to uninfected larvae.ResultsThe results predict the RLV parameter to be the most important determinant for Wolbachia invasion and establishment. Specifically, the fitness of infected immature hosts must be close to equal to that of uninfected hosts before population replacement can occur. Furthermore, minute decreases in RLV inhibit the invasion of Wolbachia despite high levels of cytoplasmic incompatibility, maternal inheritance, and low adult fitness costs.ConclusionsThe model described here takes a novel approach to understanding the spread of Wolbachia through a population with explicit dynamics. By combining a stochastic female adult lifestage and deterministic immature/adult male lifestages, the model predicts that even those Wolbachia infections that cause minor decreases in immature survival are unlikely to invade and spread within the host population. The results are discussed in relation to recent theoretical and empirical studies of natural population replacement events and proposed applied research, which would use Wolbachia as a tool to manipulate insect populations.

【 授权许可】

Unknown   
© Crain et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.