Integrated treatment vs. treatment-as-usual for recent onset schizophrenia; 12 year follow-up on a randomized controlled trial

BMC Psychiatry

Research Article

Víðir Sigrúnarson¹  Gunnar Morken¹  Rolf W Gråwe² 

[1]Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

[2]Department of Psychiatry, St. Olav’s University Hospital, Trondheim, Norway

[3]Department of Research and Development, Drug and Alcohol Treatment Health Trust in Central Norway, Trondheim, Norway

关键词: Schizophrenia;    Integrated treatment;    Early intervention;    Long term outcome;   

DOI  :  10.1186/1471-244X-13-200

 received in 2012-11-08, accepted in 2013-07-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe aim of this study is to compare the 12-year follow-up effects on in- and outpatient services of 2 years of integrated treatment for recent-onset schizophrenia versus treatment as usual in a randomized controlled trial.Methods50 patients aged 18–35 years were randomized to Integrated Treatment (IT) (N = 30) or Treatment-as-Usual (TAU) (N = 20) for two years. TAU comprised optimal pharmacotherapy and outreach assertive treatment, while IT also included cognitive-behavioural family treatment, skills training, strategies for residual psychotic and non-psychotic problems and home-based crisis management.ResultsThere were no differences in number of days in hospital, time to readmission, number of admittances to psychiatric wards, number of involuntarily psychiatric admissions or number of outpatient contacts over a period of 12 years following the initial 2-year treatment trial. Fewer patients in the IT group were, however, involuntary admitted to hospital in the period.ConclusionsThe intensive two-year psychosocial intervention seemed to have little long-term effects on use of in- and outpatient services.Trial registrationCurrent Controlled Trials: NCT00184509

【 授权许可】

CC BY   
© Sigrúnarson et al.; licensee BioMed Central Ltd. 2013