Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from a cohort study

BMC Endocrine Disorders

Research Article

Henk-Jan Aanstoot¹  Henk J. Veeze¹  Dick Mul¹  Sarah Bovenberg¹  Erwin Birnie²  Josine C. van der Heyden³ 

[1] Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Blaak 6, 3011, Rotterdam, TA, Netherlands;Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Blaak 6, 3011, Rotterdam, TA, Netherlands;Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713, Groningen, GZ, Netherlands;Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Blaak 6, 3011, Rotterdam, TA, Netherlands;Department of Pediatric Endocrinology, Sophia Children’s Hospital, Erasmus MC, University Medical Centre, Wytemaweg 80, 3015, Rotterdam, CN, Netherlands;Department of Pediatrics, Sint Franciscus Gasthuis, Kleiweg 500, 3045, Rotterdam, PM, Netherlands;

关键词: Pediatrics;    Type 1 diabetes;    Skin autofluorescence;    Skin advanced glycation end products;    Diabetic complications;   

DOI  :  10.1186/s12902-016-0129-3

 received in 2016-02-23, accepted in 2016-08-16,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundEarly identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (SAF) as a potential surrogate risk marker.MethodsThis study included a cross-sectional analysis of SAF in 77 patients with type 1 diabetes mellitus and 118 healthy controls across age categories (11–12, 13–14, 15–16, and 17–19 years old). In patients, the impact of current and historical glycated hemoglobin (HbA1c) values, age, and duration of diabetes on SAF was studied in a retrospective cohort study and analyzed with multivariable analyses.ResultsSAF was significantly and similarly higher in patients when compared with controls across all age categories (P ≤0.009). For patients, age, duration of diabetes, and current and historical HbA1c were associated with SAF in univariate analysis. Multivariate analysis showed no association between HbA1c and SAF. A subgroup of patients with a HbA1c-within-target (≤7.5 %/59 mmol/mol) were observed to have high SAF.ConclusionChildren and adolescents with type 1 diabetes show higher SAF than controls. The presumed correlation of high HbA1c with high SAF does not exist in all patients. Thus, use of this non-invasive measure may provide a surrogate marker for diabetic complications, additional to HbA1c.

【 授权许可】

CC BY   
© The Author(s). 2016