An initial loading-dose vitamin D versus placebo after hip fracture surgery: baseline characteristics of a randomized controlled trial (REVITAHIP)

BMC Geriatrics

Research Article

Jenson CS Mak¹  Terry Finnegan²  Rebecca S Mason³  Linda A Klein⁴  Ian D Cameron⁵ 

[1] Department of Geriatric Medicine, Gosford Hospital, Gosford, NSW, Australia;Rehabilitation Studies Unit, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;Department of Geriatric Medicine, Royal North Shore Hospital, Sydney, NSW, Australia;Department of Physiology, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia;Office of Medical Education, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;Rehabilitation Studies Unit, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;

关键词: Fragility fractures;    Hip fracture;    Vitamin D;    Aged care;    Metabolic bone disorders;    Osteoporosis;    Rehabilitation;    Trauma surgery;   

DOI  :  10.1186/1471-2318-14-101

 received in 2014-05-19, accepted in 2014-08-27,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundHypovitaminosis D is particularly common among older people with a proximal femoral (hip) fracture. There are currently no agreed strategies for vitamin D replenishment after hip fracture surgery. The REVITAHIP Study is a multisite, double-blinded randomized-controlled trial investigating the effects of an oral vitamin D loading dose on gait velocity after hip fracture surgery. We describe the baseline characteristics of participants, aiming to document hypovitaminosis D and its associations after hip fracture.MethodsParticipants, over 65, recruited within 7 days following hip fracture surgery from 3 Australia hospitals, were randomly allocated to receive a loading dose of vitamin D3 (250,000IU) or placebo, followed by oral maintenance vitamin D3/calcium (800 IU/500 mg) and the usual hip fracture rehabilitation pathway. Demographic and clinical data were collected, including surgical procedure, pre-fracture functional status, Mini Mental State Examination (MMSE) score, serum 25-hydroxyvitamin D (25-OHD), Verbal Rating Scale (VRS) for pain, grip strength and gait velocity. The associations of baseline 25-OHD levels with demographic and clinical data were assessed using Pearson’s correlation, ANOVA and regression analyses.ResultsTwo-hundred-and-eighteen people with hip fracture participated in the study. Mean age was 83.9+/-7.2 years, 77% were women and 82% lived in private homes. Fifty-six percent had a subcapital fracture. Mean comorbidity count was 3.13+/-2.0. Mean MMSE was 26.1+/-3.9. Forty-seven percent of participants had hypovitaminosis D (<50 nmol/L). Multivariate regression models demonstrated higher baseline vitamin D levels were significantly associated with higher premorbid Barthel index scores, lower post-operative VRS pain levels and use of vitamin D.ConclusionThis study cohort shared similar demographic characteristics and comorbidities with other cohorts of people with hip fracture, with the probable exception of less cognitive impairment. Hypovitaminosis D was not as prevalent as previously documented. Patients taking vitamin D supplements and with higher premorbid Barthel index, reflecting greater independence and activity, tended to have higher 25-OHD levels at baseline. Further, lower VRS pain ratings following surgery were associated with higher vitamin D levels. Such associations will need further investigation to determine causation. (ANZCTR number, ACTRN12610000392066).Trial registrationThe protocol for this study is registered with the Australian New Zealand Clinical Trials Registry ANZCTRN ACTRN12610000392066.

【 授权许可】

CC BY   
© Mak et al.; licensee BioMed Central Ltd. 2014