Prognostic value of a computer-aided diagnosis system involving bone scans among men treated with docetaxel for metastatic castration-resistant prostate cancer

BMC Cancer

Research Article

Shigeo Takebayashi¹  Jun-ichi Teranishi²  Hiroji Uemura²  Keiichi Kondo²  Shuko Yoneyama²  Kazumi Noguchi²  Yusuke Hattori²  Yasuhide Miyoshi²  Takashi Kawahara²  Koichi Uemura²  Yumiko Yokomizo³  Masahiro Yao³  Masatoshi Moriyama⁴ 

[1] Department of Radiology, Yokohama City University Medical Center, Yokohama, Japan;Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, 232-0024, Yokohama, Japan;Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;Department of Urology, Yokohama Municipal Citizen’s Hospital, Yokohama, Japan;

关键词: Prostate cancer;    Castration-resistant;    Survival prediction;    Bone scan index;   

DOI  :  10.1186/s12885-016-2160-1

 received in 2015-08-22, accepted in 2016-02-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe bone scan index (BSI), which is obtained using a computer-aided bone scan evaluation system, is anticipated to become an objective and quantitative clinical tool for evaluating bone metastases in prostate cancer. Here, we assessed the usefulness of the BSI as a prognostic factor in patients with metastatic castration-resistant prostate cancer (mCRPC) treated using docetaxel.MethodsWe analyzed 41 patients who received docetaxel for mCRPC. The Bonenavi system was used as the calculation program for the BSI. The utility of the BSI as a predictor of overall survival (OS) after docetaxel was evaluated. The Cox proportional hazards model was used to investigate the association between clinical variables obtained at docetaxel treatment, namely PSA, patient age, liver metastasis, local therapy, hemoglobin (Hb), lactase dehydrogenase (LDH), albumin (Alb), PSA doubling time, and BSI and OS.ResultsThe median OS after docetaxel therapy was 17.7 months. Death occurred in 22 (53.7 %) patients; all deaths were caused by prostate cancer. In multivariate analysis, three factors were identified as significant independent prognostic biomarkers for OS after docetaxel; these were liver metastases (yes vs no; HR, 3.681; p = 0.026), Alb (<3.9 vs ≥3.9; HR, 3.776; p = 0.020), and BSI (>1 % vs ≤1 %; HR, 3.356; p = 0.037). We evaluated the discriminatory ability of our models including or excluding the BSI by quantifying the c-index. The BSI improved the c-index from 0.758 to 0.769 for OS after docetaxel. CRPC patients with a BSI >1 had a significantly shorter OS than patients with a BSI ≤1 (p = 0.029).ConclusionsThe BSI, liver metastases and Alb were independent prognostic factors for OS after docetaxel. The BSI might be a useful tool for risk stratification of mCRPC patients undergoing docetaxel treatment.

【 授权许可】

CC BY   
© Uemura et al. 2016