Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies

BMC Nephrology

Research Article

Yali Ren¹  Hua Li²  Weifeng Shang²  Junwu Dong²  Yi Yang³  Yuanyuan Li⁴ 

[1] Department of Medical Affaires, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, People’s Republic of China;Department of Nephrology and Rheumatology, The Forth Hospital of Wuhan Affiliated with Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, People’s Republic of China;Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;Department of Respiratory Medicine, The Forth Hospital of Wuhan Affiliated with Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, People’s Republic of China;

关键词: Kidney stone;    Nephrolithiasis;    Hypertension;    Meta-analysis;   

DOI  :  10.1186/s12882-017-0762-8

 received in 2017-06-24, accepted in 2017-11-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundObservational studies have demonstrated an association between nephrolithiasis and hypertension. The aim of this meta-analysis was to summarize all available evidence.MethodsPubMed, EMBASE, the Cochrane Central Register of Controlled Trials databases, and the reference lists of relevant articles were searched to identify observational studies that reported study-specific risk estimates comparing the risk of hypertension in patients with nephrolithiasis. We used a random-effect model to pool the study-specific risk estimates. We also assessed the potential heterogeneity by subgroup analyses, meta-regression analyses, and sensitivity analyses.ResultsA total of 7 articles including 9 studies (n = 313,222 participants) were eventually identified in this meta-analysis. In comparison with the patients who did not have nephrolithiasis, nephrolithiasis significantly increased the risk of hypertension (OR, 1.43; 95% CI, 1.30–1.56), with significant heterogeneity between these studies (I2 = 83.5%, P <0.001). The heterogeneity reduced in subgroups of cohort studies, USA, large sample size trials, men, and adjustment for confounding factors ≥ 5. Sensitivity analysis further demonstrated the results to be robust.ConclusionsNephrolithiasis is associated with increased risk of hypertension. Future randomized, high-quality clinical trials are encouraged to definitively clarify the relationship between nephrolithiasis and hypertension, which may influence clinical management and primary prevention of hypertension in nephrolithiasis patients.

【 授权许可】

CC BY   
© The Author(s). 2017