Biomechanical parameters of the cornea measured with the Ocular Response Analyzer in normal eyes

BMC Ophthalmology

Research Article

David F Garway-Heath¹  Aachal Kotecha¹  Dimitros Sinapis¹  Richard A Russell¹  Angelos Sinapis¹  Sayeh Pourjavan² 

[1] NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, 11-43, Bath Street, EC1V 9EL, London, UK;St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium;

关键词: Axial Length;    Central Corneal Thickness;    Corneal Curvature;    Corneal Hysteresis;    Ocular Response Analyzer;   

DOI  :  10.1186/1471-2415-14-11

 received in 2013-07-05, accepted in 2014-01-24,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure.MethodsTwo hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured with the ORA. Intraocular pressure (IOP) was measured with the Dynamic Contour tonometer and central corneal thickness (CCT) was also evaluated. Partial least squares linear regression (PLSLR) analyses were performed to examine the relationships between each response variable, CH and CRF, and the predictor variables age, corneal curvature (CC), axial length (AL), CCT and IOP.ResultsCH was positively associated with CCT and negatively associated with age (scaled coefficients: CCT 0.62, p < 0.0001; age -0.55, p <0.0001; r2 = 0.25). CRF was positively associated with CCT and DCT IOP and negatively associated with age and AL (scaled coefficients: CCT 0.89, p < 0.0001; DCT IOP 0.46, p < 0.01; age – 0.60, p < 0.0001; AL -0.37, p < 0.01; r2 = 0.43). There was no significant association between CC and CH or CRF.ConclusionsThe study suggests that age and CCT are strongly associated with CH and CRF, and that the latter is also influenced by AL and IOP. However, the variables studied could explain only 25% and 43% of the measured variation in CH and CRF, respectively, suggesting other factors also affect the values of these measurements.

【 授权许可】

CC BY   
© Kotecha et al.; licensee BioMed Central Ltd. 2014