Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study

BMC Cancer

Study Protocol

Jürgen Debus¹  Thomas Welzel¹  Stephanie E Combs¹  Daniel Habermehl¹  Katia Parodi²  Christopher Kurz²  Julia Bauer²  Daniel Unholtz²  Thomas Haberer² 

[1] Department of Radiation Oncology, University Hospital of Heidelberg, INF 400, 69120, Heidelberg, Germany;Heidelberger Ionenstrahl Therapiezentrum (HIT), INF 450, 69120, Heidelberg, Germany;

关键词: Compute Tomogram;    Therapeutic Irradiation;    Particle Therapy;    Beam Range;    Treatment Planning Algorithm;   

DOI  :  10.1186/1471-2407-12-133

 received in 2012-02-20, accepted in 2012-04-03,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe purpose of this clinical study is to investigate the clinical feasibility and effectiveness of offline Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy.Methods/DesignA total of 240 patients will be recruited, evenly sampled among different analysis groups including tumors of the brain, skull base, head and neck region, upper gastrointestinal tract including the liver, lower gastrointestinal tract, prostate and pelvic region. From the comparison of the measured activity with the planned dose and its corresponding simulated activity distribution, conclusions on the delivered treatment will be inferred and, in case of significant deviations, correction strategies will be elaborated.DiscussionThe investigated patients are expected to benefit from this study, since in case of detected deviations between planned and actual treatment delivery a proper intervention (e.g., correction) could be performed in a subsequent irradiation fraction. In this way, an overall better treatment could be achieved than without any in-vivo verification. Moreover, site-specific patient-population information on the precision of the ion range at HIT might enable improvement of the CT-range calibration curve as well as safe reduction of the treatment margins to promote enhanced treatment plan conformality and dose escalation for full clinical exploitation of the promises of ion beam therapy.Trial RegistrationNCT01528670

【 授权许可】

CC BY   
© Combs et al; licensee BioMed Central Ltd. 2012