Medio-Frontal and Anterior Temporal abnormalities in children with attention deficit hyperactivity disorder (ADHD) during an acoustic antisaccade task as revealed by electro-cortical source reconstruction

BMC Psychiatry

Research Article

Johanna Kissler¹  Johanna Goepel¹  Brigitte Rockstroh¹  Isabella Paul-Jordanov¹ 

[1] Department of Psychology, University of Konstanz, Konstanz, Germany;

关键词: Attention Deficit Hyperactivity Disorder;    Anterior Cingulate Cortex;    Response Inhibition;    Control Child;    Attention Deficit Hyperactivity Disorder Child;   

DOI  :  10.1186/1471-244X-11-7

 received in 2010-09-15, accepted in 2011-01-12,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent disorders in children and adolescence. Impulsivity is one of three core symptoms and likely associated with inhibition difficulties. To date the neural correlate of the antisaccade task, a test of response inhibition, has not been studied in children with (or without) ADHD.MethodsAntisaccade responses to visual and acoustic cues were examined in nine unmedicated boys with ADHD (mean age 122.44 ± 20.81 months) and 14 healthy control children (mean age 115.64 ± 22.87 months, three girls) while an electroencephalogram (EEG) was recorded. Brain activity before saccade onset was reconstructed using a 23-source-montage.ResultsWhen cues were acoustic, children with ADHD had a higher source activity than control children in Medio-Frontal Cortex (MFC) between -230 and -120 ms and in the left-hemispheric Temporal Anterior Cortex (TAC) between -112 and 0 ms before saccade onset, despite both groups performing similarly behaviourally (antisaccades errors and saccade latency). When visual cues were used EEG-activity preceding antisaccades did not differ between groups.ConclusionChildren with ADHD exhibit altered functioning of the TAC and MFC during an antisaccade task elicited by acoustic cues. Children with ADHD need more source activation to reach the same behavioural level as control children.

【 授权许可】

CC BY   
© Goepel et al; licensee BioMed Central Ltd. 2011