Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

BMC Complementary and Alternative Medicine

Research Article

Yelamtsehay Mekonnen¹  Sirichai Adisakwattana²  Asfaw Debella³  Eyasu Makonnen⁴  Alemayehu Toma⁵ 

[1] Department of Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, 10330, Pathumwan, Bangkok, Thailand;Directorate of Traditional and Modern Drug Research, Ethiopian Public Health Institute (EPHI, Addis Ababa, Ethiopia;Pharmacology Department, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia;Pharmacology Department, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia;Pharmacology Unit, School of Medicine, Hawassa University, P.o. box 1560, Hawassa, Ethiopia;

关键词: Antihyperglycemic;    Antihyperlipidemic;    Streptozotocin;    Moringa stenopetala;    Histopathology;   

DOI  :  10.1186/s12906-015-0779-0

 received in 2015-04-27, accepted in 2015-07-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMoringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.MethodsThe aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan’s in diabetic rats. The plant material reduced the post-prandial glucose level (P < 0.001) at the dose of 750 mg/kg.ConclusionThese findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.

【 授权许可】

CC BY   
© Toma et al. 2015

【 图 表 】

12864_2017_4071_Article_IEq5.gif

12864_2015_2304_Article_IEq10.gif

12864_2017_4071_Article_IEq4.gif

12864_2017_3920_Article_IEq1.gif

12864_2016_2580_Article_IEq1.gif

12894_2016_184_Article_IEq3.gif

12894_2016_184_Article_IEq2.gif

12864_2017_4224_Article_IEq1.gif

12864_2015_2129_Article_IEq12.gif