Impact of PINCH expression on survival in colorectal cancer patients

BMC Cancer

Research Article

Johan Rosell¹  Hans Starkhammar¹  Charlotte Bratthäll¹  Xiao-Feng Sun²  Siv Doré³  Hong Zhang⁴  Jasmine Lööf⁴ 

[1] Department of Oncology, Linköping University Hospital, Linköping, Sweden;Department of Oncology, Linköping University, Linköping, Sweden;Department of Pathology, Linköping University, Linköping, Sweden;Division of Tumour Biology, Systems Biology Research Centre, University of Skövde, Skövde, Sweden;

关键词: Vascular Endothelial Growth Factor;    Colorectal Cancer Patient;    Normal Mucosa;    Lymph Vessel Density;    Invasive Margin;   

DOI  :  10.1186/1471-2407-11-103

 received in 2010-04-15, accepted in 2011-03-22,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH and survival regarding the response to chemotherapy in colorectal cancer.ResultsParaffin-embedded tissue sections from 251 primary adenocarcinomas, 149 samples of adjacent normal mucosa, 57 samples of distant normal mucosa and 75 lymph node metastases were used for immunohistochemical staining. Stromal staining for PINCH increased from normal mucosa to primary tumour to metastasis. Strong staining in adjacent normal mucosa was related to worse survival independently of sex, age, tumour location, differentiation and stage (p = 0.044, HR, 1.60, 95% CI, 1.01-2.52). PINCH staining at the invasive margin tended to be related to survival (p = 0.051). In poorly differentiated tumours PINCH staining at the invasive margin was related to survival independently of sex, age and stage (p = 0.013, HR, 1.90, 95% CI, 1.14-3.16), while in better differentiated tumours it was not. In patients with weak staining, adjuvant chemotherapy was related to survival (p = 0.010, 0.013 and 0.013 in entire tumour area, invasive margin and inner tumour area, respectively), but not in patients with strong staining. However, in the multivariate analysis no such relationship was seen.ConclusionsPINCH staining in normal adjacent mucosa was related to survival. Further, PINCH staining at the tumour invasive margin was related to survival in poorly differentiated tumours but not in better differentiated tumours, indicating that the impact of PINCH on prognosis was dependent on differentiation status.

【 授权许可】

Unknown   
© Lööf et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.