Monitoring candidate gene expression variations before, during and after a first major depressive episode in a 51-year-old man

BMC Psychiatry

Case Report

Jean-Michel Azorin¹  Raoul Belzeaux²  El Chérif Ibrahim³ 

[1] APHM, Hôpital Sainte Marguerite, Pôle de Psychiatrie Universitaire Solaris, 13274 cedex 9, Marseille, France;FondaMental, Fondation de Recherche et de Soins en Santé Mentale, Créteil, France;Aix Marseille Université, CNRS, CRN2M UMR 7286, 51 Bd Pierre Dramard, 13344 cedex 15, Marseille, France;APHM, Hôpital Sainte Marguerite, Pôle de Psychiatrie Universitaire Solaris, 13274 cedex 9, Marseille, France;FondaMental, Fondation de Recherche et de Soins en Santé Mentale, Créteil, France;Aix Marseille Université, CNRS, CRN2M UMR 7286, 51 Bd Pierre Dramard, 13344 cedex 15, Marseille, France;FondaMental, Fondation de Recherche et de Soins en Santé Mentale, Créteil, France;

关键词: mRNA;    Biomarker;    5HTT;    TNF;    Antidepressant;    Major depression;   

DOI  :  10.1186/1471-244X-14-73

 received in 2014-01-15, accepted in 2014-03-10,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAlthough psychiatric disorders are frequently characterized by clinical heterogeneity, high recurrence, and unpredictable prognosis, studies of mRNA expression variations in blood cells from psychiatric patients constitute a promising avenue to establish clinical biomarkers. We report here, to our knowledge, the first genetic monitoring of a major depressive episode (MDE).Case presentationThe subject is a 51-year-old male, who was healthy at baseline and whose blood mRNA was monitored over 67 weeks for expression variations of 9 candidate genes. At week 20 the subject experienced a mild to moderate unexpected MDE, and oral antidepressant treatment was initiated at week 29. At week 36, the patient recovered from his MDE. After 6 months, antidepressant treatment was discontinued and the subject remained free of depressive symptoms. Genetic monitoring revealed that mRNA expression of SLC6A4/5HTT increased with the emergence of a depressive state, which later returned to basal levels after antidepressant treatment and during MDE recovery. PDLIM5, S100A10 and TNF mRNA showed also an interesting pattern of expression with regards to MDE evolution.ConclusionThis case demonstrated the applicability of peripheral mRNA expression as a way to monitor the natural history of MDE.

【 授权许可】

Unknown   
© Belzeaux et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.