Association between expression of the Bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome

BMC Musculoskeletal Disorders

Research Article

Jörn Zwingmann¹  Norbert P Südkamp¹  Philipp Niemeyer¹  Hagen Schmal¹  Fabian Stoffel¹  Alexander T Mehlhorn¹ 

[1] Department of Orthopedic Surgery, University of Freiburg Medical Center, Hugstetter Str. 55, D-79106, Freiburg, Germany;

关键词: Cartilage Defect;    Cartilage Repair;    Cartilage Lesion;    Autologous Chondrocyte Implantation;    Lysholm Score;   

DOI  :  10.1186/1471-2474-11-170

 received in 2010-04-06, accepted in 2010-07-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAlthough there is much known about the role of BMPs in cartilage metabolism reliable data about the in vivo regulation in natural and surgically induced cartilage repair are still missing.MethodsLavage fluids of knee joints of 47 patients were collected during surgical therapy. 5 patients had no cartilage lesion and served as a control group, the other 42 patients with circumscribed cartilage defects were treated by microfracturing (19) or by an Autologous Chondrocyte Implantation (23). The concentrations of BMP-2 and BMP-7 were determined by ELISA. The clinical status was evaluated using the IKDC Score prior to and 1 year following the operation.ResultsHigh level expression in the control group was found for BMP-2, concentrations of BMP-7 remained below detection levels. No statistical differences could be detected in concentrations of BMP-2 or BMP-7 in the lavage fluids of knees with cartilage lesions compared to the control group. Levels of BMP-7 did not change after surgical cartilage repair, whereas concentrations of BMP-2 statistically significant increased after the intervention (p < 0.001). The clinical outcome following cartilage regenerating surgery increased after 1 year by 29% (p < 0.001). The difference of the IKDC score after 1 year and prior to the operation was used to quantify the degree of improvement following surgery. This difference statistically significant correlated with initial BMP-2 (R = 0.554, p < 0.001) but not BMP-7 (R = 0.031, n.s.) levels in the knee joints.ConclusionsBMP-2 seems to play an important role in surgically induced cartilage repair; synovial expression correlates with the clinical outcome.

【 授权许可】

CC BY   
© Schmal et al; licensee BioMed Central Ltd. 2010