Short-term efficacy of intravitreal Aflibercept injections for retinal angiomatous proliferation

BMC Ophthalmology

Research Article

Hung-Da Chou¹  Nan-Kai Wang²  Kuan-Jen Chen²  Chi-Chun Lai²  Wei-Chi Wu²  Lan-Hsin Chuang³ 

[1] Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan, Republic of China;Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan Dist., 333, Taoyuan City, Taiwan, Republic of China;School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., 333, Taoyuan City, Taiwan, Republic of China;School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., 333, Taoyuan City, Taiwan, Republic of China;Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, No. 222, Maijin Rd., Anle Dist., 204, Keelung City, Taiwan, Republic of China;

关键词: Aflibercept;    Age-related macular degeneration;    Anti-angiogenic agents;    Choroidal neovascularization;    Retinal angiomatous proliferation;    Type 3 neovascularization;   

DOI  :  10.1186/s12886-017-0497-0

 received in 2017-02-10, accepted in 2017-06-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo evaluate the short-term efficacy of intravitreal injections of aflibercept (IVA) to treat retinal angiomatous proliferation (RAP) and identify factors related to functional outcomes.MethodsThis retrospective case series consisted of 19 eyes in 19 patients with RAP. All 19 eyes received 3 monthly consecutive IVA. The primary outcome measures were best-corrected visual acuity (BCVA) and central retinal thickness (CRT) after the last IVA.ResultsOf the 19 treated eyes, 8 (42%) were pre-treated with 1 dose of bevacizumab one month prior to the initiation of treatment with aflibercept. BCVA was significantly improved and CRT was significantly reduced after 3 consecutive IVAs (P = 0.014 and P = 0.0002, respectively). Stabilization or improvement in BCVA was observed in 17 eyes (90%) treated with IVA. Eyes with baseline fibrovascular pigment epithelial detachment (PED) showed no significant gain in BCVA, and fibrovascular PED was negatively correlated with final BCVA (Spearman’s correlation coefficient = − 0.481, P = 0.037). The mean follow-up was 3.5 ± 0.5 months.ConclusionsIn this short-term study, three consecutive IVAs showed efficacy for improving vision and reducing retinal edema in RAP patients. Eyes with fibrovascular PED showed poorer responses, and the presence of fibrovascular PED at baseline was negatively correlated with visual outcomes.

【 授权许可】

CC BY   
© The Author(s). 2017