Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study

BMC Cardiovascular Disorders

Research Article

Yingxian Sun¹  Shuang Chen¹  Xiaofan Guo¹  Tan Li²  Jun Yang² 

[1] Department of Cardiology, the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, 110001, Shenyang, People’s Republic of China;Department of Cardiovascular Ultrasound, the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, 110001, Shenyang, People’s Republic of China;

关键词: Hypertension;    Diabetes;    Left ventricular remodeling;    Left ventricular geometry;   

DOI  :  10.1186/s12872-017-0642-y

 received in 2017-06-03, accepted in 2017-07-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population.MethodsA total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest.ResultsHT + DM group had higher interventricular septal thickness (IVSd), posterior wall thickness (PWTd), left ventricular mass (LVM), LVM index (LVMI), relative wall thickness (RWT), left atrial diameter (LAD), A wave and lower E wave than HT group (all P < 0.05). The prevalence rates of left ventricular hypertrophy (LVH) and abnormal geometry were statistically different among three groups (P < 0.001) and eccentric hypertrophy was the highest proportion of geometry abnormality. Logistic regression analysis suggested that subjects in HT and HT + DM groups had odds ratio (OR) values of 2.81, 4.41, 2.24 and 3.94, 7.20, 2.38 for LVH, concentric hypertrophy and eccentric hypertrophy in the total population, respectively, compared to control group. When compared with HT group, those in HT + DM group had approximately 1.40-, 1.61- and 1.38-, 1.71-fold increased risk for LVH and concentric hypertrophy in the total and female population separately, but no association of HT + DM with LVH and abnormal geometrical patterns was found in men.ConclusionsThis study demonstrated that, to varying degrees, hypertension was associated with LV remodeling in rural Chinese population, and this risk association was obviously increased for LVH and concentric hypertrophy when accompanied by diabetes, especially for women.

【 授权许可】

CC BY   
© The Author(s). 2017