Risk of placental abruption in relation to migraines and headaches

BMC Women's Health

Research Article

Chungfang Qiu¹  Tanya K Sorensen¹  Michelle A Williams²  Percy N Pacora³  Sixto E Sanchez⁴  Cande V Ananth⁵  Sheena K Aurora⁶ 

[1] Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA;Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA;Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA;Department of Obstetrics and Gynecology, Hospital Nacional Docente Madre Niño San Bartolomè; & Universidad Nacional Mayor de San Marcos, Lima, Peru;Department of Obstetrics and Gynecology, Hospital Nacional dos de Mayo, & Universidad San Martin de Porres, Lima, Peru;Division of Epidemiology and Biostatistics; Department of Obstetrics, Gynecology, and Reproductive Sciences UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA;Swedish Headache Center, Seattle, WA, USA;

关键词: Migraine;    Migraine With Aura;    Hypertensive Disorder;    Migraine Without Aura;    Lifetime History;   

DOI  :  10.1186/1472-6874-10-30

 received in 2010-04-16, accepted in 2010-10-26,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMigraine, a common chronic-intermittent disorder of idiopathic origin characterized by severe debilitating headaches and autonomic nervous system dysfunction, and placental abruption, the premature separation of the placenta, share many common pathophysiological characteristics. Moreover, endothelial dysfunction, platelet activation, hypercoagulation, and inflammation are common to both disorders. We assessed risk of placental abruption in relation to maternal history of migraine before and during pregnancy in Peruvian women.MethodsCases were 375 women with pregnancies complicated by placental abruption, and controls were 368 women without an abruption. During in-person interviews conducted following delivery, women were asked if they had physician-diagnosed migraine, and they were asked questions that allowed headaches and migraine to be classified according to criteria established by the International Headache Society. Logistic regression procedures were used to calculate odds ratios (aOR) and 95% confidence intervals (CI) adjusted for confounders.ResultsOverall, a lifetime history of any headaches or migraine was associated with an increased odds of placental abruption (aOR = 1.60; 95% CI 1.16-2.20). A lifetime history of migraine was associated with a 2.14-fold increased odds of placental abruption (aOR = 2.14; 95% CI 1.22-3.75). The odds of placental abruption was 2.11 (95% CI 1.00-4.45) for migraineurs without aura; and 1.59 (95% 0.70-3.62) for migraineurs with aura. A lifetime history of tension-type headache was also increased with placental abruption (aOR = 1.61; 95% CI 1.01-2.57).ConclusionsThis study adds placental abruption to a growing list of pregnancy complications associated with maternal headache/migraine disorders. Nevertheless, prospective cohort studies are needed to more rigorously evaluate the extent to which migraines and/or its treatments are associated with the occurrence of placental abruption.

【 授权许可】

Unknown   
© Sanchez et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.