Phylogenetic analysis of fungal ABC transporters

BMC Genomics

Research Article

Andriy Kovalchuk¹  Arnold JM Driessen¹ 

[1] Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Kerklaan 30, 9751, HAREN, NN, The Netherlands;Kluyver Centre for Genomics of Industrial Fermentation, P.O. Box 5057, 2600, Delft, GA, The Netherlands;

关键词: Fungal Genome;    Pleiotropic Drug Resistance;    Pleiotropic Drug Resistance Protein;    Pleiotropic Drug Resistance Transporter;    Secondary Metabolism Cluster;   

DOI  :  10.1186/1471-2164-11-177

 received in 2009-10-20, accepted in 2010-03-16,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied.ResultsWe performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe.ConclusionsData obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.

【 授权许可】

CC BY   
© Kovalchuk and Driessen; licensee BioMed Central Ltd. 2010