Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity

BMC Complementary and Alternative Medicine

Research Article

Aini Ideris¹  Abdul Rahman Omar¹  Parvaneh Mehrbod¹  Mohd Hair-Bejo¹ 

[1] Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang Selangor, Malaysia;Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia;

关键词: HESA-A;    H1N1;    Influenza virus;    HA;    MTT;   

DOI  :  10.1186/1472-6882-14-131

 received in 2013-09-19, accepted in 2014-03-31,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundInfluenza virus is still a severe respiratory disease affecting human and other species. As conventional drugs are not recommended for long time because of side effects and drug resistance occurrence, traditional medication has been focused as alternative remedy. HESA-A is a natural compound from herbal-marine origin. Previous studies have reported the therapeutic properties of HESA-A on psoriasis vulgaris and different types of cancers and we also showed its anti-inflammatory effects against influenza A infection.MethodsThis study was designed to investigate the potential properties of HESA-A as prophylaxis or treatment. To investigate the prophylaxis or treatment activities of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were exposed to HESA-A and influenza A virus in different manners of exposure and different time intervals. The results were evaluated by MTT and HA assays.ResultsIt was found that HESA-A is much more effective against influenza cytopathic effects when it is applied for prophylaxis and also in concurrent treatment (p ≤ 0.05) but not in post-infection treatment (p ≥ 0.05).ConclusionIn conclusion, HESA-A is significantly effective against influenza replication in prophylaxis application affecting the virus penetration/adsorption to the cell without any toxic effect on the cell viability.

【 授权许可】

Unknown   
© Mehrbod et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.