Approach to growth hormone therapy in children with chronic kidney disease varies across North America: the Midwest Pediatric Nephrology Consortium report

BMC Nephrology

Research Article

Larry A. Greenbaum¹  Christine B. Sethna²  John D. Mahan³  Amy J. Kogon³  Robert Woroniecki⁴  Oleh M. Akchurin⁵  Hoda T. Hammad⁵  Juhi Kumar⁵  Paul J. Christos⁵ 

[1]Emory University / Children’s Healthcare of Atlanta, Atlanta, USA

[2]Hofstra Northwell School of Medicine / Cohen Children’s Medical Center of New York, Hempstead, USA

[3]Ohio State University / Nationwide Children’s Hospital, Columbus, USA

[4]Stony Brook University, Stony Brook, USA

[5]Weill Cornell Medicine, New York, USA

关键词: Short stature;    Linear growth;    Chronic kidney disease;    Growth hormone;    Standards of care;    Survey;   

DOI  :  10.1186/s12882-017-0599-1

 received in 2017-02-12, accepted in 2017-05-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGrowth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization in short children with CKD. Despite efforts at consensus guidelines, lack of high-level evidence continues to complicate rhGH therapy decision-making and the level of practice variability in rhGH treatment by pediatric nephrologists is unknown.MethodsCross-sectional online survey electronically distributed to pediatric nephrologists through the Midwest Pediatric Nephrology Consortium and American Society of Pediatric Nephrology.ResultsSeventy three pediatric nephrologists completed the survey. While the majority (52.1%) rarely involve endocrinology in rhGH management, 26.8% reported that endocrinology managed most aspects of rhGH treatment in their centers. The majority of centers (68.5%) have a dedicated renal dietitian, but 20.6% reported the nephrologist as the primary source of nutritional support for children with CKD. Children with growth failure did not receive rhGH most commonly because of family refusal. Differences in initial work-up for rhGH therapy include variable use of bone age (95%), thyroid function (58%), insulin-like growth factor-1 (40%), hip/knee X-ray (36%), and ophthalmologic evaluation (7%). Most pediatric nephrologists (95%) believe that rhGH treatment improves quality of life, but only 24% believe that it improves physical function; 44% indicated that rhGH improves lean body mass.ConclusionsThere is substantial variation in pediatric nephrology practice in addressing short stature and rhGH utilization in children with CKD. Hence, there may be opportunities to standardize care to study and improve growth outcomes in short children with CKD.

【 授权许可】

CC BY   
© The Author(s). 2017