Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows

BMC Genomics

Research Article

George R Wiggans¹  John B Cole¹  Curtis P Van Tassell²  Tad S Sonstegard³  Lakshmi K Matukumalli³  Li Ma⁴  Yang Da⁴  Shengwen Wang⁴  Brian A Crooker⁴  Jing Yang⁴  Thomas J Lawlor⁵ 

[1] Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA;Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA;Bovine Functional Genomics Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA;Bovine Functional Genomics Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA;Department of Animal Science, University of Minnesota, St. Paul, Minnesota, USA;Holstein Association USA, Brattleboro, Vermont, USA;

关键词: Single Nucleotide Polymorphism Marker;    Somatic Cell Score;    BTA1;    Single Nucleotide Polymorphism Effect;    Significant Single Nucleotide Polymorphism;   

DOI  :  10.1186/1471-2164-12-408

 received in 2010-10-01, accepted in 2011-08-11,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundGenome-wide association analysis is a powerful tool for annotating phenotypic effects on the genome and knowledge of genes and chromosomal regions associated with dairy phenotypes is useful for genome and gene-based selection. Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows.ResultsGenome-wide association analysis identified a number of candidate genes and chromosome regions associated with 31 dairy traits in contemporary U.S. Holstein cows. Highly significant genes and chromosome regions include: BTA13's GNAS region for milk, fat and protein yields; BTA7's INSR region and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate, somatic cell score and productive life; BTA2's LRP1B for somatic cell score; BTA14's DGAT1-NIBP region for fat percentage; BTA1's FKBP2 for protein yields and percentage, BTA26's MGMT and BTA6's PDGFRA for protein percentage; BTA18's 53.9-58.7 Mb region for service-sire and daughter calving ease and service-sire stillbirth; BTA18's PGLYRP1-IGFL1 region for a large number of traits; BTA18's LOC787057 for service-sire stillbirth and daughter calving ease; BTA15's CD82, BTA23's DST and the MOCS1-LRFN2 region for daughter stillbirth; and BTAX's LOC520057 and GRIA3 for daughter pregnancy rate. For body conformation traits, BTA11, BTAX, BTA10, BTA5, and BTA26 had the largest concentrations of SNP effects, and PHKA2 of BTAX and REN of BTA16 had the most significant effects for body size traits. For body shape traits, BTAX, BTA19 and BTA3 were most significant. Udder traits were affected by BTA16, BTA22, BTAX, BTA2, BTA10, BTA11, BTA20, BTA22 and BTA25, teat traits were affected by BTA6, BTA7, BTA9, BTA16, BTA11, BTA26 and BTA17, and feet/legs traits were affected by BTA11, BTA13, BTA18, BTA20, and BTA26.ConclusionsGenome-wide association analysis identified a number of genes and chromosome regions associated with 31 production, health, reproduction and body conformation traits in contemporary Holstein cows. The results provide useful information for annotating phenotypic effects on the dairy genome and for building consensus of dairy QTL effects.

【 授权许可】

Unknown   
© Cole et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.