Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis

BMC Infectious Diseases

Research Article

Weihong Qin¹  Yaobo Liang¹  Yaping Li¹  Yue Feng²  Li Zhang²  Zulqarnain Baloch²  Binghui Wang²  Yajuan Wang²  Xueshan Xia²  Jiejie Dai³  Yunzhang Hu³  Henglin Yang⁴  Hongning Zhou⁴ 

[1] Care center for International travel health in Yunnan, Kunming, China;Faculty of Life Science and Technology, Center for Molecular medicine in Yunnan Province, Kunming University of Science and Technology, Kunming, China;Institute of Molecular Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China;Yunnan Research Institute of parasitic disease control, Kunming, China;

关键词: Dengue virus;    Viral outbreak;    Phylogenetic analysis;    Bayesian analysis;    Imported infection;   

DOI  :  10.1186/s12879-015-0908-x

 received in 2014-12-19, accepted in 2015-03-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAn outbreak of dengue virus (DENV) occurred in Yunnan province. More than 2,000 individuals were infected from August to November 2013. In this study, we aimed to characterize the origin and prevalence of DENV in Dehong prefecture of Yunnan province using phylogenetic and evolutionary analyses of DENV strains collected from local patients and foreign travelers.MethodsA total of 41 DENV-positive serum samples were randomly collected from travelers who entered China at Ruili port or local patients with dengue fever in Dehong prefecture of Yunnan province, China. The envelope (E) gene of DENV was amplified and sequenced. The distributions and evolutionary characteristics of different genotypes were elucidated by phylogenetic and Bayesian analyses.ResultsPhylogenetically, all of the 41 DENV-positive samples could be classified into genotype I (43.9%) of serotype DENV-1 and the Asian I genotype (56.1%) of serotype DENV-2. DENV strains derived from local patients and foreign travelers were scattered equally within these two clusters. Furthermore, the DENV strains from the two populations exhibited high relatedness based on evolutionary characteristics.ConclusionsThese results suggested that imported and local DENV strains occurring during the dengue outbreak in 2013 were highly related. Additionally, these data may suggest that this dengue outbreak was caused by a newly imported infection from the neighboring country of Myanmar.

【 授权许可】

Unknown   
© Wang et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.