Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman’s disease

BMC Ophthalmology

Case Report

Liangchun Wang¹  Yuqin Lan²  Mei Wang²  Haijun Gong²  Yuxin Hu²  Hong Zeng³  Qingyu Liu⁴  Shiyou Zhou⁵ 

[1] Department of Dermatology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Department of Pathology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, 510120, Guangzhou, China;

关键词: Corneal melting;    Paraneoplastic pemphigus;    Castleman’s disease;   

DOI  :  10.1186/s12886-016-0280-7

 received in 2015-07-22, accepted in 2016-06-17,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe ocular presentation of Castleman’s disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis.Case presentationWe describe a case of 23-year-old male with mucocutaneous erosion and conjunctival injection and erosion who was found to have PNP. Pelvic hyaline-vascular CD was detected and completely excised. The mucocutaneous lesions improved postoperatively. Two years after pelvic surgery, the patient gradually developed conjunctival symblepharon in both eyes and pterygium in the right eye. The patient then underwent a successful exclusion of the symblepharon, an excision of the pterygium and an amniotic membrane transplantation in the right eye. However, after 6 months, he experienced an aseptic corneal ulcer and recurrent pterygiumin the right eye. After treatment with systemic and local immunosuppressive medications, the corneal ulcer gradually healed and remained stable.ConclusionCorneal ulceration and melting, in addition to conjunctivitis, as a complication of CD-associated PNP, can be successfully managed with systemic and local immunosuppressants.

【 授权许可】

CC BY   
© The Author(s). 2016