Gene polymorphisms in association with emerging cardiovascular risk markers in adult women

BMC Medical Genetics

Research Article

Ali H Mokdad¹  Man-huei Chang²  Amy Z Fan²  Jing Fang²  Nicole F Dowling²  Donald Hayes²  Ajay Yesupriya²  Renée Ned²  Meaghan House³ 

[1] Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Avenue Suite600, 98121, Seattle, WA, USA;National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, 30333, Atlanta, GA, USA;School of Public Health, Emory University, 1518 Clifton Road NE, 30329, Atlanta, GA, USA;

关键词: Homocysteine;    Serum Uric Acid;    Serum Uric Acid Level;    Plasma Fibrinogen;    Drinking Status;   

DOI  :  10.1186/1471-2350-11-6

 received in 2009-06-05, accepted in 2010-01-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundEvidence on the associations of emerging cardiovascular disease risk factors/markers with genes may help identify intermediate pathways of disease susceptibility in the general population. This population-based study is aimed to determine the presence of associations between a wide array of genetic variants and emerging cardiovascular risk markers among adult US women.MethodsThe current analysis was performed among the National Health and Nutrition Examination Survey (NHANES) III phase 2 samples of adult women aged 17 years and older (sample size n = 3409). Fourteen candidate genes within ADRB2, ADRB3, CAT, CRP, F2, F5, FGB, ITGB3, MTHFR, NOS3, PON1, PPARG, TLR4, and TNF were examined for associations with emerging cardiovascular risk markers such as serum C-reactive protein, homocysteine, uric acid, and plasma fibrinogen. Linear regression models were performed using SAS-callable SUDAAN 9.0. The covariates included age, race/ethnicity, education, menopausal status, female hormone use, aspirin use, and lifestyle factors.ResultsIn covariate-adjusted models, serum C-reactive protein concentrations were significantly (P value controlling for false-discovery rate ≤ 0.05) associated with polymorphisms in CRP (rs3093058, rs1205), MTHFR (rs1801131), and ADRB3 (rs4994). Serum homocysteine levels were significantly associated with MTHFR (rs1801133).ConclusionThe significant associations between certain gene variants with concentration variations in serum C-reactive protein and homocysteine among adult women need to be confirmed in further genetic association studies.

【 授权许可】

CC BY   
© Fan et al; licensee BioMed Central Ltd. 2010