Evoked potentials and behavioral performance during different states of brain arousal

BMC Neuroscience

Research Article

Tilman Hensch¹  Jue Huang¹  Christian Sander²  Christine Ulke²  Philippe Jawinski²  Ulrich Hegerl²  Janek Spada³ 

[1] Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany;Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany;Depression Research Centre, German Depression Foundation, Leipzig, Germany;Depression Research Centre, German Depression Foundation, Leipzig, Germany;

关键词: VIGALL;    Brain arousal;    EEG-vigilance stage;    Evoked potential;    Oddball paradigm;    Behavioral performance;   

DOI  :  10.1186/s12868-017-0340-9

 received in 2016-06-09, accepted in 2017-01-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPrevious studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before sleep onset. Recently, the Vigilance Algorithm Leipzig (VIGALL 2.0) has been developed, which automatically attributes one out of seven EEG-vigilance stages to each 1-s EEG segment, ranging from stage 0 (associated with cognitively active wakefulness), to stages A1, A2 and A3 (associated with relaxed wakefulness), to stages B1 and B2/3 (associated with drowsiness) up to stage C (indicating sleep onset). Applying VIGALL, we specified the effects of these finely differentiated EEG-vigilance stages (indicating arousal states) on EPs (P1, N1, P2, N300, MMN and P3) and behavioral performance. Subjects underwent an ignored and attended condition of a 2-h eyes-closed oddball-task. Final analysis included 43 subjects in the ignored and 51 subjects in the attended condition. First, the effect of brain arousal states on EPs and performance parameters were analyzed between EEG-vigilance stages A (i.e. A1, A2 and A3 combined), B1 and B2/3&C (i.e. B2/3 and C combined). Then, in a second step, the effects of the finely differentiated EEG-vigilance stages were further specified.ResultsComparing stages A versus B1 versus B2/3&C, a significant effect of EEG-vigilance stages on all behavioral parameters and all EPs, with exception of MMN and P3, was found. By applying VIGALL, a more detailed view of arousal effects on EP and performance was possible, such as the finding that the P2 showed no further significant increase in stages deeper than B1. Stage 0 did not differ from any of the A-stages. Within more fine-graded stages, such as the A-substages, EPs and performance only partially differed. However, these analyses were partly based on small sample sizes and future studies should take effort to get enough epochs of rare stages (such as A3 and C).ConclusionsA clear impact of arousal on EPs and behavioral performance was obtained, which emphasize the necessity to consider arousal effects when interpreting EPs.

【 授权许可】

CC BY   
© The Author(s) 2017

【 图 表 】

12888_2017_1557_Article_IEq9.gif

12864_2016_2682_Article_IEq29.gif

12864_2017_4363_Article_IEq4.gif

12864_2015_2137_Article_IEq11.gif

12888_2017_1557_Article_IEq4.gif

12864_2017_4020_Article_IEq25.gif

12888_2017_1557_Article_IEq2.gif

12864_2017_3487_Article_IEq67.gif

12864_2017_4020_Article_IEq22.gif

12864_2017_3777_Article_IEq21.gif

12864_2017_4132_Article_IEq45.gif

12864_2017_4020_Article_IEq20.gif

12864_2017_4133_Article_IEq43.gif

12864_2017_3487_Article_IEq62.gif

12864_2015_2198_Article_IEq15.gif

12864_2017_4269_Article_IEq1.gif

12864_2017_3605_Article_IEq20.gif

12864_2015_2297_Article_IEq17.gif

12864_2017_3655_Article_IEq6.gif

12864_2017_4190_Article_IEq10.gif

12864_2017_4190_Article_IEq9.gif

12864_2017_3605_Article_IEq16.gif