Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses

BMC Cancer

Research Article

George A. Kelley¹  Kristi S. Kelley² 

[1] Meta-Analytic Research Group, School of Public Health, Department of Biostatistics, Director, WVCTSI Clinical Research Design, Epidemiology, and Biostatistics (CRDEB) Program, PO Box 9190, Robert C. Byrd Health Sciences Center, Room 2350-A, 26506-9190, Morgantown, West Virginia, USA;Meta-Analytic Research Group, School of Public Health, Department of Biostatistics, PO Box 9190, Robert C. Byrd Health Sciences Center, Room 2350-B, 26506-9190, Morgantown, West Virginia, USA;

关键词: Exercise;    Cancer;    Fatigue;    Meta-analysis;    Systematic review;   

DOI  :  10.1186/s12885-017-3687-5

 received in 2017-04-12, accepted in 2017-10-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundConduct a systematic review of previous systematic reviews with meta-analysis to determine the effects of exercise (aerobic, strength or both) on cancer-related-fatigue (CRF) in adults with any type of cancer.MethodsSystematic reviews with meta-analyses of previous randomized controlled trials published through July of 2016 were included by searching six electronic databases and cross-referencing. Dual-selection and data abstraction were conducted. Methodological quality was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) instrument. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI), number needed-to-treat (NNT) and percentile improvements were calculated.ResultsSixteen studies representing 2 to 48 SMD effect sizes per analysis (mean ± SD, 7 ± 8, median = 5) and 37 to 3254 participants (mean ± SD, 633 ± 690, median = 400) were included. Length of training lasted from 3 to 52 weeks (mean ± SD, 14.6 ± 3.1, median = 14), frequency from 1 to 10 times per week (mean ± SD, 3.4 ± 0.8, median = 3), and duration from 10 to 120 min per session (mean ± SD, 44.3 ± 5.5, median = 45). Adjusted AMSTAR scores ranged from 44.4% to 80.0% (mean ± SD, 68.8% ± 12.0%, median = 72.5%). Overall, mean SMD improvements in CRF ranged from −1.05 to −0.01, with 22 of 55 meta-analytic results (52.7%) statistically significant (non-overlapping 95% CI). When PI were calculated for results with non-overlapping 95% CI, only 3 of 25 (12%) yielded non-overlapping 95% PI favoring reductions in CRF. Number needed-to-treat and percentile improvements ranged from 3 to 16 and 4.4 to 26.4, respectively.ConclusionsA lack of certainty exists regarding the benefits of exercise on CRF in adults. However, exercise does not appear to increase CRF in adults.Trial registrationPROSPERO Registration # CRD42016045405.

【 授权许可】

CC BY   
© The Author(s). 2017