Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes

Basic and Clinical Andrology

Research Article

Kaoru Yanagida¹  Teruaki Iwamoto¹  Satoru Takamizawa¹  Hiroyuki Nishiyama²  Miki Yoshiike³  Kazumitsu Yamasaki⁴  Kaoru Yoshida⁵  Kazuhiko Shimada⁶ 

[1] Center for IVF and Infertility, International University of Health and Welfare Hospital, Nasushiobara, Japan;Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;Department of Urology, St Marianna University School of Medicine, Kawasaki, Japan;Department of Urology, Tsukuba Gakuen Hospital, Tsukuba, Japan;Center for IVF and Infertility, International University of Health and Welfare Hospital, Nasushiobara, Japan;Faculty of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan;Institute for Central Clinic, Shimotsuke, Japan;Center for IVF and Infertility, International University of Health and Welfare Hospital, Nasushiobara, Japan;

关键词: Seminal plasma protein;    Male infertility;    Sperm motility;    Semenogelin;    IUI;    IVF;    ICSI;    Pregnancy outcomes;   

DOI  :  10.1186/s12610-017-0059-6

 received in 2017-03-28, accepted in 2017-07-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSemenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG’s sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted.MethodsTo reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients. The pregnancy outcomes in partners of these patients were retrospectively analyzed using questionnaires.ResultsAmong examined semen parameters, only the total SEMG-unbound sperm count showed a tendency to be different between the spontaneous pregnancy or intra-uterine-insemination-pregnancy groups and in-vitro-fertilization- or intracytoplasmic-sperm-injection-pregnancy groups. It was elevated in the former group, which includes patients who used in vivo fertilization.ConclusionsThe total SEMG-unbound sperm count would be a relevant parameter for in vivo fertilization. This result suggests that SEMGs inhibit ectopic capacitation before sperm reach the fertilization site and that the number of total SEMG-unbound sperm is a parameter directly linked to the possibility of in vivo fertilization.

【 授权许可】

CC BY   
© The Author(s). 2017