Osteopontin, asbestos exposure and pleural plaques: a cross-sectional study

BMC Public Health

Research Article

Aline SC Fabricio¹  Silvia Michilin¹  Massimo Gion²  Giuseppe Mastrangelo³  Luca Cegolon⁴  John H Lange⁵  Flavio Valentini⁶  Maria N Ballarin⁷  Gianluca Marangi⁷  Ugo Fedeli⁸ 

[1] ABO Association, Regional Centre for the Study of Biological Markers of Malignancy, Department of Clinical Pathology, Local Health Authority 12, Venice, Italy;Department of Clinical Pathology, Regional Centre for the Study of Biological Markers of Malignancy, Primary Care Trust 12, Venice, Italy;Department of Environmental Medicine and Public Health, Padua University, Padua, Italy;Department of Environmental Medicine and Public Health, Padua University, Padua, Italy;Imperial College London, School of Public Health, St. Mary's Campus, London, UK;Envirosafe Training and Consultants, P.O. Box 114022, 15239-0522, Pittsburgh, PA, USA;Occupational Health Service, Occupational Health Service, Primary Care Trust 13, Dolo (Venice), Italy;Occupational Health Service, Primary Care Trust 12, Venice, Italy;Regional Epidemiological Service, Veneto Region, Castelfranco Veneto (TV), Italy;

关键词: Malignant Pleural Mesothelioma;    Chrysotile;    Asbestos Exposure;    Occupational Health Service;    Peak Exposure;   

DOI  :  10.1186/1471-2458-11-220

 received in 2010-08-20, accepted in 2011-04-08,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundOsteopontin (OPN) is a plasma protein/cytokine produced in excess in several malignancies. In a recent study OPN was reported as being related to the duration of asbestos exposure and presence of benign asbestos-related diseases; however, it was unclear whether this protein was an indicator of exposure or effect.MethodsIn 193 workers, 50 with pleural plaques (PP), in whom different indicators of past asbestos exposure were estimated, OPN plasma levels were assessed using commercial quantitative sandwich enzyme immunoassays according to the manufacturer's instructions.ResultsOsteopontin increased with increasing age and several aspects of asbestos exposure, without differences related to the presence of pleural plaques. At multivariable regression analysis, the explanatory variables with a significant independent influence on OPN were length of exposure (positive correlation) and time elapsed since last exposure (positive correlation).ConclusionsSince asbestos in lung tissue tends to wane over time, OPN should decrease (rather than increase) with time since last exposure. Therefore, OPN cannot be a reliable biomarker of exposure nor effect (presence of pleural plaques).

【 授权许可】

Unknown   
© Mastrangelo et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.