Psychological stress and coeliac disease in childhood: a cohort study

BMC Gastroenterology

Research Article

Karl Mårild¹  Jonas F Ludvigsson²  Anneli Sepa Frostell³ 

[1] Astrid Lindgren Children's Hospital, Karolinska University Hospital, Solna, Sweden;Department of Medicine, Örebro University, Örebro, Sweden;Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;Department of Paediatrics, Örebro University Hospital, Örebro, Sweden;Department of Clinical and Experimental Medicine, Division of Paediatrics and Diabetes Research Centre, Linköping University, Sweden;

关键词: Parenting Stress;    Psychological Stress;    Coeliac Disease;    Villous Atrophy;    Parental Worry;   

DOI  :  10.1186/1471-230X-10-106

 received in 2009-08-24, accepted in 2010-09-14,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundPsychological stress has previously been associated with several immunological diseases, e.g. inflammatory bowel disease. Through questionnaire data from the ABIS study (All Babies In southeast Sweden) we examined the association between psychological stress in the family and biopsy-proven coeliac disease (CD) in the child.MethodsWe used serious life event, parenting stress, and parental worries as measures of psychological stress. Data were collected when the child was 1 and 2.5 years old in some 11,000 and 8,800 children, respectively. CD was confirmed through small intestinal biopsy (with villous atrophy), and the diagnosis was validated through patient chart data.ResultsSerious life event in the family in the child's first 1 or 2.5 years after childbirth was not associated with future CD in the child (Odds Ratio (OR) = 0.45; 95% Confidence Interval (CI) = 0.01-2.65; P = 0.72; and OR = 1.21; 95% CI = 0.43-3.05; P = 0.64, respectively). Neither did we see any association between CD and parenting stress at age 1 year and at 2.5 years (OR = 0.40; 95% CI = 0.01-2.38; P = 0.73 and OR = 0.74; 95% CI = 0.01-4.56; P = 1.00, respectively). Among children exposed to parental worries at 2.5 years, no child had a diagnosis of CD before end of follow-up, compared to 25/8082 (0.3%) among non-exposed children (OR = 0.00; 95% CI = 0.00-2.34; P = 0.64). There was no association between the combined measures of stress and CD.ConclusionThis study found no association between psychological stress and later development of CD in Swedish children. However, we cannot rule out that the lack of such an association is due to limited statistical power.

【 授权许可】

CC BY   
© Mårild et al; licensee BioMed Central Ltd. 2010