Preoperative cholesterol level as a new independent predictive factor of survival in patients with metastatic renal cell carcinoma treated with cyto-reductive nephrectomy

BMC Cancer

Research Article

Eu Chang Hwang¹  Yong June Kim²  Sung-Hoo Hong³  Seok Ho Kang⁴  Tae Gyun Kwon⁵  Jinsoo Chung⁶  Sung Kyu Hong⁷  Hakmin Lee⁷  Sang Eun Lee⁷  Jong Jin Oh⁷  Sang Chul Lee⁷  Seok-Soo Byun⁸  Cheol Kwak⁹  Hyeon Hoe Kim⁹ 

[1] Department of Urology, Chonnam National University Hwasun Hospital, Hwasun, South Korea;Department of Urology, Chungbuk National University College of Medicine, Cheongju, South Korea;Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea;Department of Urology, Korea University School of Medicine, Seoul, South Korea;Department of Urology, Kyungpook National University College of Medicine, Daegu, South Korea;Department of Urology, National Cancer Center, Goyang, South Korea;Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea;Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea;Department of Urology, Seoul National University College of Medicine, Seoul, South Korea;Seoul National University Bundang Hospital, Seongnam, South Korea;Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea;

关键词: Renal cell carcinoma;    Cholesterol;    Survival;    Metastasis;    Hypercholesterolemia;   

DOI  :  10.1186/s12885-017-3322-5

 received in 2017-02-07, accepted in 2017-05-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative cholesterol level (PCL) and survival outcomes in patients with mRCC.MethodsWe analysed the data of 244 patients initially treated with cyto-reductive nephrectomy after being diagnosed with mRCC. Patients were stratified into two groups according to the PCL cut-off level of 170 mg/dL. The postoperative survival rates were compared using Kaplan-Meier analysis and the possible predictors of patients’ cancer-specific survival (CSS) and overall survival (OS) were tested using multivariate Cox-proportional hazard models.ResultsThe low cholesterol group showed significantly worse postoperative CSS (p = 0.013) and OS (p = 0.009) than the high cholesterol group. On multivariate analysis, low PCL was revealed as an independent predictor of worse CSS (hazard ratio [HR], 2.162; 95% CI, 1.221–3.829; p = 0.008) and OS (HR, 2.013; 95% CI, 1.206–3.361; p = 0.007). Subsequent subgroup analysis showed that these results were maintained in the clear cell subgroup but not in the non-clear cell subgroup.ConclusionDecreased PCL was significantly correlated with worse survival outcomes in patients with mRCC treated with cytoreductive nephrectomy. The underlined mechanism is still uncharted and requires further investigation.

【 授权许可】

CC BY   
© The Author(s). 2017