Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)

BMC Public Health

Research Article

Paulo R Menezes¹  Paulo A Lotufo¹  Isabela M Benseñor²  Márcia Scazufca³ 

[1] Hospital Universitário, University of Sao Paulo, Sao Paulo, Brazil;School of Medicine, University of Sao Paulo, Sao Paulo, Brazil;Hospital Universitário, University of Sao Paulo, Sao Paulo, Brazil;School of Medicine, University of Sao Paulo, Sao Paulo, Brazil;Hospital das Clínicas, University of Sao Paulo, Sao Paulo, Brazil;School of Medicine, University of Sao Paulo, Sao Paulo, Brazil;Hospital das Clínicas, University of Sao Paulo, Sao Paulo, Brazil;Hospital João Evangelista, São Paulo, Brazil;

关键词: Dementia;    Thyroid Stimulate Hormone;    Vascular Dementia;    Iodine Intake;    Subclinical Hypothyroidism;   

DOI  :  10.1186/1471-2458-10-298

 received in 2009-12-21, accepted in 2010-06-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSeveral epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older peopleMethodsA cross-sectional study - São Paulo Ageing & Health Study (SPAH) - in a population sample of low-income elderly people ≥ 65 years-old to evaluate presence of subclinical thyroid disease as a risk factor for dementia. Thyroid function was assessed using thyrotropic hormone and free-thyroxine as well as routine use of thyroid hormones or antithyroid medications. Cases of dementia were assessed using a harmonized one-phase dementia diagnostic procedure by the "10/66 Dementia Research Group" including Alzheimer's disease and vascular dementia. Logistic regression models were used to test a possible association between subclinical hyperthyroidism and dementia.Results and discussionPrevalence of dementia and of subclinical hyperthyroidism were respectively of 4.4% and 3.0%. After age adjustment, we found an association of subclinical hyperthyroidism and any type of dementia and vascular dementia (Odds Ratio, 4.1, 95% Confidence Interval [95% CI] 1.3-13.1, and 5.3 95% CI, 1.1-26.4; respectively). Analyzing data by gender, we found an association of subclinical hyperthyroidism with dementia and Alzheimer's disease only for men (OR, 8.0; 95% CI, 1.5-43.4; OR, 12.4; 95% CI, 1.2-128.4; respectively). No women with subclinical hypothyroidism presented Alzheimer's disease in the sample.ConclusionThe results suggest a consistent association among people with subclinical hyperthyroidism and dementia.

【 授权许可】

CC BY   
© Benseñor et al; licensee BioMed Central Ltd. 2010