Cysticlean® a highly pac standardized content in the prevention of recurrent urinary tract infections: an observational, prospective cohort study

BMC Urology

Research Article

Ana María Oltra Benavent¹  Vicente Ruiz Vidal²  Francisco Sánchez Ballester³  Emilio López Alcina³  Cristina Domenech Perez⁴  Ana Montoliu García⁵  Eva Escudero Fontano⁵  Marco Andrés Sobrón Bustamante⁵ 

[1] Nephrology Department, Hospital Lluis Alcanyis de Xativa, Valencia, Spain;Primary Health Care, Clínica Comarcal Atenea Aldaia, Valencia, Spain;Urodynamics Unit, Hospital Quirón, Avenida de Vicente Blasco Ibañez 14, 46010, Valencia, Spain;Urology Department, Consorcio Hospital General Universitario, Valencia, Spain;Urology Department Hospital de la Malvarrosa, University of Valencia, Valencia, Spain;Urology Department, Consorcio Hospital General Universitario, Valencia, Spain;

关键词: Cranberry;    Cysticlean®;    Cystitis;    Postcoital;    QoL;    Urinary tract infections;   

DOI  :  10.1186/1471-2490-13-28

 received in 2013-01-09, accepted in 2013-05-22,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean®) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL).MethodsThis was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment.ResultsThe number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean® was 2.8±1.3 and it was reduced to 0.2±0.5 at Month 6 (P<0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4±19.1, increasing to 78.2±12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P<0.001). The most common bacterium was Escherichia coli.ConclusionsProphylaxis with American cranberry extract (Cysticlean®) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.

【 授权许可】

CC BY   
© Sánchez Ballester et al.; licensee BioMed Central Ltd. 2013