Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report

BMC Gastroenterology

Case Report

Cristina Popescu¹  Victoria Arama¹  Smaranda Gliga¹ 

[1] 'Matei Bals' National Institute of Infectious Diseases, University of Medicine and Pharmacy 'Carol Davila' Bucharest, Grozovici 1, sector 2, Romania;

关键词: Interferon;    Pericardial Effusion;    Pericarditis;    Interferon Therapy;    Cryoglobulinemia;   

DOI  :  10.1186/1471-230X-11-30

 received in 2010-12-05, accepted in 2011-03-31,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCardio toxicity due to interferon therapy was reported only in small case series or case reports. The most frequent cardiac adverse effects related to interferon are arrhythmias and ischemic manifestations. The cardiomyopathy and pericarditis are rare but can be life threatening. The predisposing factors for interferon cardio toxicity were described only for ischemic manifestations and arrhythmias.Case presentationThe authors report a case of pericarditis due to alpha interferon therapy for chronic hepatitis C, in a young woman without previous cardiac pathology. The clinical manifestations started during the 7-th month of interferon treatment. The cessation of interferon was necessary. After interferon discontinuation the patient recovered, with complete resolution of pericarditis. The patient scored 9 points on the Naranjo ADR probability scale, indicating a very probable association between pericarditis and interferon administration.ConclusionIf a patient receiving interferon therapy complains of chest pain of sudden onset, a cardiac ultrasound should be performed in order to rule out pericarditis. We point out the possibility of an infrequent but severe adverse effect of interferon therapy.

【 授权许可】

CC BY   
© Popescu et al; licensee BioMed Central Ltd. 2011