Antidepressant-like activity of turmerone in behavioral despair tests in mice

BMC Complementary and Alternative Medicine

Research Article

Wen-Huang Peng¹  Hui-Chi Huang¹  Chia-Yu Liu²  Jen-Chieh Tsai³  Lung-Yuan Wu⁴  Jung-Chun Liao⁵ 

[1] Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, No. 91, Hsueh-Shih Road, 404, Taichung, Taiwan;Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, No. 91, Hsueh-Shih Road, 404, Taichung, Taiwan;Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management, No. 79-9, Sha-Luen-Hu, Xi Zhou Li, 35664, Hou-Loung Town, Miaoli County, Taiwan;Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 404, Taiwan;School of Chinese Medicine for Post Baccalaureate, I-Shou university, No.1, Sec. 1, Syuecheng Rd, 84001, Dashu District, Kaohsiung City, Taiwan;School of Pharmacy, College of Pharmacy, China Medical University, 404, Taichung, Taiwan;

关键词: Tumerone;    Forced swimming test;    Tail suspension test;    Antidepressant;    Monoamines;   

DOI  :  10.1186/1472-6882-13-299

 received in 2013-08-07, accepted in 2013-10-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe present study was undertaken to evaluate the anti-depressive activity of turmerone after one-week administration by using a mouse forced swimming test (FST) and tail suspension test (TST).MethodsAnimals were divided into four groups (n = 10 /group): control (0.9% saline), the three doses of turmerone (1.25, 2.5, 5.0 mg/kg) for one-week treatment. To assess the effect of turmerone on locomotor activity, mice were evaluated in the open-field paradigm. Forced swimming test (FST) and Tail suspension test (TST) were used to take as a measure of antidepressant activity. The probable mechanisms of action of the anti-depressive effect of turmerone was also investigated by measuring the activity of monoamine oxidase-A and corticosterone levels in the blood and the levels of monoamines in the cortex, striatum, hippocampus and hypothalamus of the mice.ResultsTurmerone (2.5, 5.0 mg/kg, p.o.) significantly reduced the immobility time of mice in both the FST and TST, but it did not significantly affect the ambulatory and total movements of mice. However, hyperactivity might explain the results. In addition, turmerone decreased the corticosterone level in the blood while it increased the levels of 5-HT in cortex, striatum, hippocampus, and hypothalamus, the level of NE in striatum and hippocampus, the levels of MHPG and DOPAC in hypothalamus, the level of 5-HIAA in striatum, and the level of DA in striatum, hippocampus, and hypothalamus. Turmerone (2.5, 5.0 mg/kg) decreased the activity of MAO-A in the frontal cortex and hippocampus of mouse brain.ConclusionsAfter one-week administration, turmerone produced antidepressant-like effects. The mechanisms of action of anti-depressive effect of turmerone seemed to involve an increase of the monoamines level decreasing the MAO-A activity and the stress of mice.

【 授权许可】

Unknown   
© Liao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.