Evaluation of Salvadora persica L. and green tea anti-plaque effect: a randomized controlled crossover clinical trial

BMC Complementary and Alternative Medicine

Research Article

Wan Harun Himratul-Aznita¹  Nor Adinar Baharuddin²  Hayder Raad Abdulbaqi³ 

[1] Department of Oral Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia;Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia;Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia;Present address: Department of Periodontics, College of Dentistry, University of Baghdad, P.O. Box 1417, Bab-Almoadham, Baghdad, Iraq;

关键词: Salvadora;    Tea;    Dental plaque;    Mouthwash;    Clinical trial;   

DOI  :  10.1186/s12906-016-1487-0

 received in 2016-07-26, accepted in 2016-11-25,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIn the author’s earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adherence effects against primary plaque colonizers biofilm. A clinical trial was needed to support these preliminary in vitro results and to investigate its efficacy as a mouthwash in the control of dental plaque.MethodsA 24 h plaque re-growth, double-blinded, randomized crossover trial was carried out. Participants (n = 14) randomly rinsed with test formulation, 0.12% chlorhexidine (control) and placebo mouthwashes for 24 h. A week before the trial, all participants received scaling, polishing and oral hygiene education. On the trial day, the participants received polishing at baseline and rinsed with 15 ml of randomly allocated mouthwash twice daily without oral hygiene measures. After 24 h, plaque index was scored and then the participants entered a 6-days washout period with regular oral hygiene measures. The same protocol was repeated for the next 2 mouthwashes.ResultsThe results were expressed as mean (±SD) plaque index. The test mouthwash (0.931 ± 0.372) significantly reduced plaque accumulation when compared with placebo (1.440 ± 0.498, p < 0.0167) and chlorhexidine (1.317 ± 0.344, p < 0.0167) mouthwashes. No significant difference was found between chlorhexidine and placebo (p > 0.0167).ConclusionsThe test mouthwash has an anti-plaque effect for a 24 h period. Longer-term clinical studies are highly encouraged to investigate its anti-plaque effect for longer periods.Trial registrationThis study was registered in ClinicalTrials.gov as NCT02624336 in December 3, 2015.

【 授权许可】

CC BY   
© The Author(s). 2016