Risk factors associated with symptomatic cholelithiasis in Taiwan: a population-based study

BMC Gastroenterology

Research Article

Shih-Chang Hung¹  Kuan-Fu Liao²  Wen-Chi Chen³  Shih-Wei Lai⁴  Chia-Ing Li⁵ 

[1] Department of Emergency Medicine, Nantou Hospital, 540, Nantou, Taiwan;Department of Public Health, China Medical University, 404, Taichung, Taiwan;Department of Internal Medicine, Taichung Tzu Chi General Hospital, 427, Taichung, Taiwan;School of Medicine, Tzu Chi University, 970, Hualien, Taiwan;School of Chinese Medicine, China Medical University, 404, Taichung, Taiwan;Department of Urology, China Medical University Hospital, 404, Taichung, Taiwan;School of Medicine, China Medical University, 404, Taichung, Taiwan;Department of Family Medicine, China Medical University Hospital, 404, Taichung, Taiwan;School of Medicine, China Medical University, 404, Taichung, Taiwan;Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan;

关键词: cholelithiasis;    hepatitis B;    hepatitis C;    hyperlipidemia;    menopause;    obesity;   

DOI  :  10.1186/1471-230X-11-111

 received in 2011-05-19, accepted in 2011-10-17,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCholelithiasis has become a major health problem in Taiwan. The predominant type of gallstone found in Asian populations differs from that in the West, indicating possible differences in the etiology and risk factors for cholelithiasis. The aim of this study is to investigate the risk factors for cholelithiasis using data representative of the general population.MethodsWe performed a population-based, case-control study in which we analyzed medical data for 3725 patients newly diagnosed with cholelithiasis and 11175 gender- and age-matched controls with no history of cholelithiasis, using information obtained from the 2005 Registry for Beneficiaries of the National Health Insurance Research Database. Coexisting medical conditions were included in the analysis. Relative risks were estimated by adjusted odds ratio (OR) and 95% confidence interval (CI) using a multivariate logistic regression analysis.ResultsAfter controlling for the other covariates, multivariate logistic regression analysis identified the following as risk factors for cholelithiasis (in descending order of contribution): Among all patients - hepatitis C (OR = 2.78), cirrhosis (OR = 2.47), hepatitis B (OR = 2.00), obesity (OR = 1.89), and hyperlipidemia (OR = 1.54); Among women - hepatitis C (OR = 3.05), cirrhosis (OR = 1.92), obesity (OR = 1.91), menopause (OR = 1.61), hepatitis B (OR = 1.54), and hyperlipidemia (OR = 1.49). Diabetes mellitus appeared to have a marked influence on the development of cholelithiasis but was not identified as a significant independent risk factor for cholelithiasis.ConclusionsThe risk factors for cholelithiasis were obesity, hyperlipidemia, hepatitis B infection, hepatitis C infection, and cirrhosis in both genders, and menopause in females. Despite differences in the predominate type of gallstone in Asian versus Western populations, we identified no unique risk factors among the population of Taiwan.

【 授权许可】

Unknown   
© Hung et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.