Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy

Cancer Nanotechnology

Review

Chun Li¹  Jun Zhao¹  Min Zhou² 

[1]Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Road, 77054, Houston, TX, USA

[2]Institute of Translational Medicine, Zhejiang University, 310009, Hangzhou, Zhejiang, China

关键词: Nanoparticles;    Radiotherapy;    Radiosensitization;    Radioisotopes;   

DOI  :  10.1186/s12645-016-0022-9

 received in 2016-06-09, accepted in 2016-11-02,  发布年份 2016

来源: Springer

【 摘 要 】

Radiotherapy has been, and will continue to be, a critical modality to treat cancer. Since the discovery of radiation-induced cytotoxicity in the late 19th century, both external and internal radiation sources have provided tremendous benefits to extend the life of cancer patients. Despite the dramatic improvement of radiation techniques, however, one challenge persists to limit the anti-tumor efficacy of radiotherapy, which is to maximize the deposited dose in tumor while sparing the rest of the healthy vital organs. Nanomedicine has stepped into the spotlight of cancer diagnosis and therapy during the past decades. Nanoparticles can potentiate radiotherapy by specifically delivering radionuclides or radiosensitizers into tumors, therefore enhancing the efficacy while alleviating the toxicity of radiotherapy. This paper reviews recent advances in synthetic nanoparticles for radiotherapy and radiosensitization, with a focus on the enhancement of in vivo anti-tumor activities. We also provide a brief discussion on radiation-associated toxicities as this is an area that, up to date, has been largely missing in the literature and should be closely examined in future studies involving nanoparticle-mediated radiosensitization.

【 授权许可】

CC BY   
© The Author(s) 2016

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