Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts

BMC Surgery

Research Article

Toshiji Tominaga¹  Tsukasa Hotta¹  Yoshimasa Oku¹  Kenji Matsuda¹  Shozo Yokoyama¹  Hiroki Yamaue¹  Toru Nasu¹  Koichi Tamura¹  Junji Ieda¹  Katsunari Takifuji¹ 

[1] Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, 641-8510, Wakayama, Japan;

关键词: Lymph Node;    Colorectal Cancer;    Liver Metastasis;    Histological Type;    Endoscopic Submucosal Dissection;   

DOI  :  10.1186/1471-2482-10-8

 received in 2009-09-30, accepted in 2010-03-08,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe differences between the metastatic property of moderately (Mod) and well (Wel) differentiated colorectal adenocarcinoma remain unclear. Since Mod is unable to form complete acini, therefore an epithelial-mesenchymal transition (EMT) can occur in that structure. Herein, we hypothesized that Mod metastasizes more easily than the Wel counterparts.MethodsThe medical records of 283 consecutive patients with Mod (n = 71) or Wel (n = 212) who underwent surgery were reviewed between January 1, 2001, and December 31, 2003, for actual 5-year overall survival. We examined the differences between the clinicopathological characteristics of the Mod and the Wel groups.ResultsThe lymph node involvement (p < 0.0001), lymphatic permeation, venous permeation, depth of invasion, liver metastasis, and carcinomatous peritonitis were significantly higher in the Mod group in comparison to the Wel group. The independent risk factors by a logistic regression analysis for lymph node involvement were as follows: lymphatic permeation, liver metastasis, and Mod (p = 0.0291, Relative Risk of 1.991: 95% Confidence Interval: 1.073-3.697). A Kaplan-Meier survival curve showed that Mod had a trend towards a poor survival (p = 0.0517).ConclusionMod metastasizes to the lymph nodes more easily in comparison to Wel. Therefore, patients with Mod may be considered the existence of lymph node involvement.

【 授权许可】

Unknown   
© Yokoyama et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.