Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer

BMC Cancer

Research Article

Jann Mortensen¹  Andreas Kjaer¹  Karina Juhl¹  Morten Persson¹  Christian von Buchwald²  Birgitte Wittenborg Charabi²  David Hebbelstrup Jensen²  Anders Christensen³  Katalin Kiss⁴  Giedrius Lelkaitis⁴  Anne Lyngholm Sørensen⁵  Julie Lyng Forman⁵ 

[1] Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Otolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark;

关键词: Oral squamous cell carcinoma;    uPAR;    Tissue factor;    EGFR;    prognosis;    immunohistochemistry;    margins;    oral cancer;    molecular imaging;   

DOI  :  10.1186/s12885-017-3563-3

 received in 2017-02-15, accepted in 2017-08-17,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhibit enhanced expression in many types of cancers, and have been investigated as potential biomarkers for targeted strategies and prognostication. The aim of the study was to investigate the expression patterns of uPAR, TF and EGFR and their potential prognostic value in OSCC.MethodsImmunohistochemical expression of uPAR, TF and EGFR in tumor resection specimens from 191 patients with primary OSCC was analyzed. Overall (OS) and disease-free survival (DFS) was calculated. Associations between biomarker expression, clinicopathological factors and patient survival was analyzed using the Cox proportional hazards model for univariate and multivariate analysis, log rank and Kaplan-Meier statistics.ResultsuPAR and TF exhibited a highly tumor-specific expression pattern while EGFR also showed expression in normal tissues outside the tumor compartment. The overall positive expression rate of uPAR, TF and EGFR was 95%, 58% and 98%, respectively. High uPAR expression across the entire cohort was negatively associated with OS (p = 0.031, HR = 1.595 (95%CI 1.044–2.439)) in univariate analysis. The 5-year OS for high and low uPAR expression was 39% and 56%, respectively. The expression of TF and EGFR was not associated with survival outcome.ConclusionsThis study may suggest that uPAR and TF could potentially be attractive targets for molecular imaging and therapy in OSCC due to high positive expression rates and tumor-specific expression patterns. High uPAR expression was significantly associated with a reduced survival. uPAR seems to be a prognostic biomarker in oral cancer.

【 授权许可】

CC BY   
© The Author(s). 2017