No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents

BMC Psychiatry

Research Article

Junko Kawatani¹  Daiki Toyohisa¹  Mai Ono¹  Shota Nishitani²  Kazuyuki Shinohara²  Akemi Tomoda³  Takashi X Fujisawa⁴  Naomi Matsuura⁵ 

[1] Department of Child Development, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;Department of Neurobiology& Behavior Unit of Basic Medical Sciences Course of Medical & Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;Research Center for Child Mental Development, University of Fukui, Fukui, Japan;Research Center for Child Mental Development, University of Fukui, Fukui, Japan;Department of Neurobiology& Behavior Unit of Basic Medical Sciences Course of Medical & Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;School of Education, Tokyo University and Graduate School of Social Welfare, Tokyo, Japan;

关键词: Child depression;    Gene-by-environment (G × E) interaction;    5-HTTLPR);    Early adversity;   

DOI  :  10.1186/1471-244X-13-134

 received in 2013-01-25, accepted in 2013-04-16,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundIdentification of gene × environment interactions (G × E) for depression is a crucial step in ascertaining the mechanisms underpinning the disorder. Earlier studies have indicated strong genetic influences and numerous environmental risk factors. In relation to childhood and adolescent depression, evidence is accumulating that the quality of the parental environment is associated with serotonin biology in children. We hypothesized that maternal depression is a crucial environmental risk factor associated with serotonin-regulating genes.MethodsThis study was designed to ascertain the G × E interaction for diagnosis of depression in a Japanese pediatric sample. DNA samples from 55 pediatric patients with depression and 58 healthy schoolchildren were genotyped for the 5-HTT (2 short (S) alleles at the 5-HTT locus) promoter serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphism. We examined whether an adverse parental environment, operationalized as the mother’s history of recurrent major depressive disorder, interacts with 5-HTTLPR polymorphism to predict patients’ depression symptoms.ResultsBinary logistic regression analyses revealed that maternal depression (adversity), gender, and FSIQ significantly affect the diagnosis of depression among children and adolescents. However, no main effect was found for adversity or genotype. Results of multivariable logistic regression analyses using stepwise procedure have elicited some models with a good fit index, which also suggests no interaction between 5-HTTLPR and adversity on depression.ConclusionsTo assess G × E interaction, data obtained from children and adolescents who had been carefully diagnosed categorically and data from age-matched controls were analyzed using logistic regression. Despite an equivocal interaction effect, adversity and gender showed significant main effects.

【 授权许可】

CC BY   
© Tomoda et al.; licensee BioMed Central Ltd. 2013