Acyl-CoA synthetase long-chain 5 genotype is associated with body composition changes in response to lifestyle interventions in postmenopausal women with overweight and obesity: a genetic association study on cohorts Montréal-Ottawa New Emerging Team, and Complications Associated with Obesity

BMC Medical Genetics

Research Article

Kristi Adamo¹  Mary-Ellen Harper²  Abishankari Rajkumar³  Gilles Lamothe⁴  Remi Rabasa-Lhoret⁵  Pierrette Bolongo⁶  Frédérique Tesson⁷  Éric Doucet⁸  Denis Prud’homme⁹ 

[1] CHEO Research Institute, Ottawa, ON, Canada;Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada;School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada;Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada;Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada;Départment de Nutrition, Université de Montréal, Montreal, QC, Canada;Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada;Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada;Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada;Faculty of Health Sciences, 451 Smyth, K1H 8M5, Ottawa, ON, Canada;School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada;School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada;Institut de recherche de l’Hôpital Montfort, Hôpital Montfort, Ottawa, ON, Canada;

关键词: Genotype;    Obesity;    Lifestyle modifications;    Fat metabolism;   

DOI  :  10.1186/s12881-016-0320-4

 received in 2015-10-24, accepted in 2016-08-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundGenetic studies on Acyl-CoA Synthetase Long-Chain 5 (ACSL5) demonstrate an association between rs2419621 genotype and rate of weight loss in women with obesity in response to caloric restriction. Our objectives were to (1) confirm results in two different populations of women with overweight and obesity (2) study rs2419621’s influence on body composition parameters of women with overweight and obesity following lifestyle interventions.Methodsrs2419621 genotype was determined in women with overweight and obesity who participated in the Montréal-Ottawa New Emerging Team (MONET n = 137) and Complications Associated with Obesity (CAO n = 37) studies. Genotyping was done using TaqMan MGB probe-based assay. Multiple linear regression analyses were used to test for associations.ResultsWhen studying women with overweight and obesity, rs2419621 [T] allele carriers had a significantly greater decrease in visceral fat, absolute and percent fat mass and a greater increase in percent lean mass in response to lifestyle intervention in comparison to non-carriers. Studying only individuals with obesity showed similar results with rs2419621 [T] allele carriers also displaying a significantly greater decrease in body mass index following the lifestyle intervention in comparison to non-carriers.ConclusionWomen with overweight and obesity carrying the ACSL5 rs2419621 [T] allele are more responsive to lifestyle interventions in comparison to non-carriers. Conducting such genetic association studies can aid in individualized treatments/interventions catered towards an individual’s genotype.

【 授权许可】

CC BY   
© The Author(s). 2016