Excessive substance use in bipolar disorder is associated with impaired functioning rather than clinical characteristics, a descriptive study

BMC Psychiatry

Research Article

Sara Larsson¹  Akiah O Berg¹  Petter A Ringen¹  Ingrid Agartz²  Kjetil Sundet³  Trine V Lagerberg⁴  Ingrid Melle⁵  Ole A Andreassen⁵ 

[1] Institute of Psychiatry, University of Oslo, Box 1130, N-0318, Blindern, Oslo, Norway;Institute of Psychiatry, University of Oslo, Box 1130, N-0318, Blindern, Oslo, Norway;Department of Research and Development, Diakonhjemmet Hospital, Box 23, N-0319, Oslo, Norway;Institute of Psychology, University of Oslo, Box 1094, N-0317, Blindern, Oslo, Norway;Section for Psychosis Research, Oslo University Hospital, Bygg 49, Kirkevn. 166, N-0407, Oslo, Norway;Section for Psychosis Research, Oslo University Hospital, Bygg 49, Kirkevn. 166, N-0407, Oslo, Norway;Institute of Psychiatry, University of Oslo, Box 1130, N-0318, Blindern, Oslo, Norway;

关键词: Bipolar Disorder;    Illicit Substance;    Young Mania Rate Scale;    Bipolar Disorder Patient;    Excessive Substance;   

DOI  :  10.1186/1471-244X-10-9

 received in 2009-08-07, accepted in 2010-01-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is a strong association between bipolar disorder (BD) and substance use disorder (SUD). The clinical and functional correlates of SUD in BD are still unclear and little is known about the role of excessive substance use that does not meet SUD criteria. Thus, the aims of the current study were to investigate lifetime rates of illicit substance use in BD relative to the normal population and if there are differences in clinical and functional features between BD patients with and without excessive substance use.Methods125 consecutively recruited BD in- and outpatients from the Oslo University Hospitals and 327 persons randomly drawn from the population in Oslo, Norway participated. Clinical and functional variables were assessed. Excessive substance use was defined as DSM-IV SUD and/or excessive use according to predefined criteria.ResultsThe rate of lifetime illicit substance use was significantly higher among patients compared to the reference population (OR = 3.03, CI = 1.9-4.8, p < .001). Patients with excessive substance use (45% of total) had poorer educational level, occupational status, GAF-scores and medication compliance, with a trend towards higher suicidality rates, compared to patients without. There were no significant group differences in current symptom levels or disease course between groups.ConclusionThe percentage of patients with BD that had tried illicit substances was significantly higher than in the normal population. BD patients with excessive substance use clearly had impaired functioning, but not a worse course of illness compared to patients without excessive substance use. An assessment of substance use beyond SUD criteria in BD is clinically relevant.

【 授权许可】

CC BY   
© Lagerberg et al; licensee BioMed Central Ltd. 2010