Bio-Repository of DNA in stroke (BRAINS): A study protocol

BMC Medical Genetics

Study Protocol

Ranil de Silva¹  Philippe Froguel²  Padma Shrivastav³  Kameshwar Prasad³  Ankita Maheshwari³  Julia Slark⁴  Sunaina Yadav⁴  Pankaj Sharma⁴  Muhammad Saleem Khan⁴  Renata Schanz⁴  Paul Bentley⁴  Jaspal Kooner⁵ 

[1] Department of Anatomy, University of Sri Jayewardenepura, Nugegoda, Sri Lanka;Department of Genomics of Common Diseases, Imperial College London, UK;Department of Neurology, All India Institute of Medical Sciences, New Delhi, India;Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, UK;National Heart and Lung Institute, Imperial College London, UK;

关键词: Stroke Patient;    Haemorrhagic Stroke;    Data Collection Form;    Factor Versus Leiden;    Stroke Service;   

DOI  :  10.1186/1471-2350-12-34

 received in 2011-01-06, accepted in 2011-03-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundStroke is one of the commonest causes of mortality in the world and anticipated to be an increasing burden to the developing world. Stroke has a genetic basis and identifying those genes may not only help us define the mechanisms that cause stroke but also identify novel therapeutic targets. However, large scale highly phenotyped DNA repositories are required in order for this to be achieved.MethodsThe proposed Bio-Repository of DNA in Stroke (BRAINS) will recruit all subtypes of stroke as well as controls from two different continents, Europe and Asia. Subjects recruited from the UK will include stroke patients of European ancestry as well as British South Asians. Stroke subjects from South Asia will be recruited from India and Sri Lanka. South Asian cases will also have control subjects recruited.DiscussionWe describe a study protocol to establish a large and highly characterized stroke biobank in those of European and South Asian descent. With different ethnic populations being recruited, BRAINS has the ability to compare and contrast genetic risk factors between those of differing ancestral descent as well as those who migrate into different environments.

【 授权许可】

Unknown   
© Yadav et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.