Effect of low-magnitude different-frequency whole-body vibration on subchondral trabecular bone microarchitecture, cartilage degradation, bone/cartilage turnover, and joint pain in rabbits with knee osteoarthritis

BMC Musculoskeletal Disorders

Research Article

Liu Lei¹  Wang Junbo¹  Wang Pu²  Chen Hongying³  Liu Sijia⁴ 

[1] Department of Orthopaedics, West China Hospital, Sichuan University, GuoXue Road 37, 610041, Chengdu, Sichuan, People’s Republic of China;Department of rehabilitation medicine, Ruijin hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China;Department of Rehabilitation Science, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China;Rui Jin Rehabilitation Hospital, Shanghai, People’s Republic of China;Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, People’s Republic of China;Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China;

关键词: Whole-body vibration;    Trabecular bone microarchitecture;    Cartilage;    Knee osteoarthritis;   

DOI  :  10.1186/s12891-017-1579-0

 received in 2016-10-31, accepted in 2017-05-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroudWhole-body vibration(WBV) has been suggested for the prevention of subchondral bone loss of knee osteoarthritis (OA) . This study examined the effects of different frequency of whole-body vibration on subchondral trabecular bone microarchitecture, cartilage degradation and metabolism of the tibia and femoral condyle bone, and joint pain in an anterior cruciate ligament transection (ACLT)–induced knee osteoarthritisrabbit model.MethodNinety adult rabbits were divided into six groups: all groups received unilateral ACLT; Group 1, ACLT only; Group 2, 5 Hz WBV; Group 3, 10 Hz WBV; Group 4, 20 Hz WBV; Group 5, 30 Hz WBV; and Group 6, 40 Hz WBV. Pain was tested via weight-bearing asymmetry. Subchondral trabecular bone microarchitecture was examined using in vivo micro-computed tomography. Knee joint cartilage was evaluated by gross morphology, histology, and ECM gene expression level (aggrecan and type II collagen [CTX-II]). Serum bone-specific alkaline phosphatase, N-mid OC, cartilage oligometric protein, CPII, type I collagen, PIIANP, G1/G2 aggrecan levels, and urinary CTX-II were analyzed.ResultsAfter 8 weeks of low-magnitude WBV, the lower frequency (10 Hz and 20 Hz) WBV treatment decreased joint pain and cartilage resorption, accelerated cartilage formation, delayed cartilage degradation especially at the 20 Hz regimen. However, the higher frequencies (30 Hz and 40 Hz) had worse effects, with worse limb function and cartilage volume as well as higher histological scores and cartilage resorption. In contrast, both prevented loss of trabeculae and increased bone turnover. No significant change was observed in the 5 Hz WBV group.ConclusionOur data demonstrate that the lower frequencies (10 Hz and 20 Hz) of low-magnitude WBV increased bone turnover, delayed cartilage degeneration, and caused a significant functional change of the OA-affected limb in ACLT-induced OA rabbit model but did not reverse OA progression after 8 weeks of treatment.

【 授权许可】

CC BY   
© The Author(s). 2017