Prosthetic joint infection caused by Granulicatella adiacens: a case series and review of literature

BMC Musculoskeletal Disorders

Case Report

Jean-Christophe Lagier¹  Florence Fenollar¹  Fanny Quénard²  Andreas Stein³  Piseth Seng³ 

[1] Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU–Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France;Centre de Référence des Infections Ostéo-Articulaires (CRIOA) Sud-Méditerranée, Assistance Publique - Hôpitaux de Marseille, IHU–Méditerranée Infection, 19–21 Boulevard Jean Moulin, 13005, Marseille, France;Centre de Référence des Infections Ostéo-Articulaires (CRIOA) Sud-Méditerranée, Assistance Publique - Hôpitaux de Marseille, IHU–Méditerranée Infection, 19–21 Boulevard Jean Moulin, 13005, Marseille, France;Service de Maladies Infectieuses Tropicales et Infections Chroniques (MITIC), IHU–Méditerranée Infection, 19–21 Boulevard Jean Moulin, 13005, Marseille, France;Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU–Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France;

关键词: Prosthetic joint infection;    Arthroplasty;    Granulicatella adiacens;    Nutritionally variant streptococcus;    Osteoarthritis;    Arthritis;    Infection;    Bacteria;    Human;   

DOI  :  10.1186/s12891-017-1630-1

 received in 2016-09-07, accepted in 2017-06-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBone and joint infection involving Granulicatella adiacens is rare, and mainly involved in cases of bacteremia and infectious endocarditis. Here we report three cases of prosthetic joint infection involving G. adiacens that were successfully treated with surgery and prolonged antimicrobial treatment. We also review the two cases of prosthetic joint infection involving G. adiacens that are reported in the literature.Case presentationNot all five cases of prosthetic joint infection caused by G. adiacens were associated with bacteremia or infectious endocarditis. Dental care before the onset of infection was observed in two cases. The median time delay between arthroplasty implantation and the onset of infection was of 4 years (ranging between 2 and 10 years). One of our cases was identified with 16srRNA gene sequencing, one case with MALDI-TOF mass spectrometry, and one case with both techniques. Two literature cases were diagnosed by 16srRNA gene sequencing. All five cases were cured after surgery including a two-stage prosthesis exchange in three cases, a one-stage prosthesis exchange in one case, and debridement, antibiotics, irrigation, and retention of the prosthesis in one case, and prolonged antimicrobial treatment.ConclusionProsthetic joint infection involving G. adiacens is probably often dismissed due to difficult culture or misdiagnosis, in particular in the cases of polymicrobial infection. Debridement, antibiotics, irrigation, and retention of the prosthesis associated with prolonged antimicrobial treatment (≥ 8 weeks) should be considered as a treatment strategy for prosthetic joint infection involving G. adiacens.

【 授权许可】

CC BY   
© The Author(s). 2017