BMC Cancer | |
Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non–small-cell lung cancer | |
Research Article | |
Katsuhiro Omae1  Keita Mori1  Masahiro Endo2  Takashi Aoyama3  Hitomi Shiozaki3  Akira Tanuma4  Takeshi Ishii4  Yoshiyuki Masuda4  Taro Okayama4  Takuya Ohashi5  Akira Ono6  Toshiaki Takahashi6  Tetsuhiko Taira6  Tateaki Naito6  Shota Omori6  Kazuhisa Nakashima6  Haruyasu Murakami6  Kazushige Wakuda6  Hirotsugu Kenmotsu6  Madoka Kimura7  Takuya Oyakawa8  Hisao Imai9  Nobuyuki Yamamoto1,10  | |
[1] Division of Clinical Research Center, Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Shizuoka, Japan;Division of Diagnostic Radiology, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Nutrition, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Rehabilitation Medicine, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Rehabilitation Medicine, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Physical Medicine and Rehabilitation, Shizuoka General Hospital, 4-27-1 Kita Ando Aoi-ku, 420-8527, Shizuoka City, Japan;Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Department of Clinical Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Tosei-ku, 537-8511, Osaka, Japan;Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Cardiology, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Sunto-gun, 411-8777, Shizuoka, Japan;Division of Respiratory Medicine, Gunma Prefectural Cancer Center, 617-1 Takabayashi-nishi-machi, Ohta-shi, 373-8550, Gunma, Japan;Third Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama-city, Japan; | |
关键词: Non–small cell lung cancer; Incremental shuttle walking distance; Hand-grip strength; Skeletal muscle mass; Sarcopenia; Cancer cachexia; | |
DOI : 10.1186/s12885-017-3562-4 | |
received in 2017-01-08, accepted in 2017-08-17, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundElderly patient with advanced cancer is one of the most vulnerable populations. Skeletal muscle depletion during chemotherapy may have substantial impact on their physical function. However, there is little information about a direct relationship between quantity of muscle and physical function. We sought to explore the quantitative association between skeletal muscle depletion, and muscle strength and walking capacity in elderly patients with advanced non–small cell lung cancer (NSCLC).MethodsThirty patients aged ≥70 years with advanced NSCLC (stage III-IV) scheduled to initiate first-line chemotherapy were prospectively enrolled between January 2013 and November 2014. Lumbar skeletal muscle index (LSMI, cm2/m2), incremental shuttle walking distance (ISWD, m), and hand-grip strength (HGS, kg) were assessed at baseline, and 6 ± 2 weeks (T2) and 12 ± 4 weeks (T3) after study enrollment. Associations were analyzed using linear regression.ResultsAltogether, 11 women and 19 men with a median age of 74 (range, 70–82) years were included in the study; 24 received cytotoxic chemotherapy and 6, gefitinib. Mean ± standard deviation of LSMI, ISWD and HGS were 41.2 ± 7.8 cm2/m2, 326.0 ± 127.9 m, and 29.3 ± 8.5 kg, respectively. LSMI and ISWD significantly declined from baseline to T2 and T3. HGS significantly declined from baseline to T2 and T3 only in men. Change in LSMI was significantly associated with change in HGS (β = 0.3 ± 0.1, p = 0.0127) and ISWD (β = 8.8 ± 2.4, p = 0.0005).ConclusionsSkeletal muscle depletion accompanied with physical functional decline started in the early phase of the chemotherapy in elderly patients with advanced NSCLC. Our results suggest that there may be a need for early supportive care in these patients to prevent functional decline during chemotherapy.Trial registrationTrial registration number: UMIN000009768Name of registry: UMIN (University hospital Medical Information Network).URL of registry: Date of registration: 14 January 2013.Date of enrolment of the first participant to the trial: 23 January 2013.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
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RO202311096846433ZK.pdf | 1061KB | download |
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