Association between CHADS2 score, depressive symptoms, and quality of life in a general population

BMC Psychiatry

Research Article

Guo-Zhe Sun¹  Zhao Li¹  Ye Chang¹  Ying-Xian Sun¹  Nai-Jin Zhang¹  Shuang Chen¹  Ning Ye¹  Yuan Li¹ 

[1] Department of Cardiovascular Medicine, The First Hospital of China Medical University, 155 Nanjing Street, Heping, 110001, Shenyang, Liaoning, China;

关键词: CHADS score;    Patient Health Questionnaire-9;    World Health Organization Quality of Life Brief Scale;    Depressive symptoms;    Quality of life;   

DOI  :  10.1186/s12888-017-1214-5

 received in 2016-07-09, accepted in 2017-01-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo investigate the association between CHADS2 score, depressive symptoms, and quality of life in a large general population from China.MethodsA cross-sectional study of 11,956 permanent residents of Liaoning Province in China ≥ 35 years of age was conducted between January and August 2013 (response rate 85.3%). All participants completed a questionnaire, had a physical examination, and underwent blood examination. Depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9), while the quality of life (QoL) was measured using the World Health Organization Quality of Life Brief Scale (WHOQOL-BREF).ResultsWith increasing CHADS2 score, the prevalence of depressive symptoms increased from 4.9 to 27.8% (P < 0.001), and all scores of WHOQOL-BREF decreased significantly (all Ps < 0.001). After adjusting for confounding risk factors, subjects with CHADS2 score ≥ 3 had higher risk of depressive symptoms than those with CHADS2 score = 0 (all Ps < 0.05). Also, CHADS2 score was negatively associated with all scores of WHOQOL-BREF (all Ps < 0.001). Furthermore, subjects with any item in CHADS2 had higher prevalence of depressive symptoms (all Ps < 0.001). Heart failure and stroke remained independently associated with depressive symptoms after adjusting for confounding risk factors and other items (Ps < 0.001), while heart failure, age ≥ 75 years, diabetes mellitus, and stroke were all independently negatively associated with the total score of WHOQOL-BREF (all Ps < 0.05).ConclusionsThe CHADS2 score is significantly associated with depressive symptoms and impaired quality of life in the general population.

【 授权许可】

CC BY   
© The Author(s). 2017