Temporal evolution of brain cancer incidence in the municipalities of Navarre and the Basque Country, Spain

BMC Public Health

Research Article

Nerea Larrañaga¹  Aritz Adin²  María Dolores Ugarte²  Tomás Goicoa³  Itziar Casado⁴  Eva Ardanaz⁵ 

[1] CIBER of Epidemiology an Public Health CIBERESP, Madrid, Spain;Public Health Division of Gipuzkoa, BIODonostia Research Institute, Government of the Basque Country, Nafarroa hiribidea 4, 20013, Donostia-San Sebastián, Spain;Department of Statistics and O.R., Public University of Navarre, Campus de Arrosadía, 31006, Pamplona, Spain;Institute for Advanced Materials (INAMAT), Public University of Navarre, Campus de Arrosadía, 31006, Pamplona, Spain;Department of Statistics and O.R., Public University of Navarre, Campus de Arrosadía, 31006, Pamplona, Spain;Institute for Advanced Materials (INAMAT), Public University of Navarre, Campus de Arrosadía, 31006, Pamplona, Spain;Research Network on Health Services in Chronic Diseases (REDISSEC), Madrid, Spain;Navarre Public Health Institute, Calle Leyre 15, 31006, Pamplona, Spain;Navarre Public Health Institute, Calle Leyre 15, 31006, Pamplona, Spain;CIBER of Epidemiology an Public Health CIBERESP, Madrid, Spain;

关键词: Brain cancer incidence;    Small areas;    Space-time models;    Relative risks;   

DOI  :  10.1186/s12889-015-2354-5

 received in 2015-07-20, accepted in 2015-09-23,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBrain cancer incidence rates in Spain are below the European’s average. However, there are two regions in the north of the country, Navarre and the Basque Country, ranked among the European regions with the highest incidence rates for both males and females. Our objective here was two-fold. Firstly, to describe the temporal evolution of the geographical pattern of brain cancer incidence in Navarre and the Basque Country, and secondly, to look for specific high risk areas (municipalities) within these two regions in the study period (1986–2008).MethodsA mixed Poisson model with two levels of spatial effects is used. The model also included two levels of spatial effects (municipalities and local health areas). Model fitting was carried out using penalized quasi-likelihood. High risk regions were detected using upper one-sided confidence intervals.ResultsResults revealed a group of high risk areas surrounding Pamplona, the capital city of Navarre, and a few municipalities with significant high risks in the northern part of the region, specifically in the border between Navarre and the Basque Country (Gipuzkoa). The global temporal trend was found to be increasing. Differences were also observed among specific risk evolutions in certain municipalities.ConclusionsBrain cancer incidence in Navarre and the Basque Country (Spain) is still increasing with time. The number of high risk areas within those two regions is also increasing. Our study highlights the need of continuous surveillance of this cancer in the areas of high risk. However, due to the low percentage of cases explained by the known risk factors, primary prevention should be applied as a general recommendation in these populations.

【 授权许可】

CC BY   
© Ugarte et al. 2015

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