Ramelteon combined with an α1-blocker decreases nocturia in men with benign prostatic hyperplasia

BMC Urology

Research Article

Satoshi Morita¹  Hitoshi Ishiguro²  Hiroshi Miyamoto²  Katsuyuki Tanaka³  Hideyuki Terao⁴  Junichi Matsuzaki⁴  Hiroki Ito⁵  Takashi Kawahara⁶  Hiroji Uemura⁷  Yoshinobu Kubota⁷  Ryoko Sakata⁷ 

[1] Department of Biostatistics and Epidemiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA;Department of Urology, Kanagawa Rehabilitation Hospital, Atsugi, Kanagawa, Japan;Department of Urology, Ohguchi Higashi General Hospital, Yokohama, Kanagawa, Japan;Department of Urology, Ohguchi Higashi General Hospital, Yokohama, Kanagawa, Japan;Department of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-kuYokohama, Kanagawa, Japan;Department of Urology, Ohguchi Higashi General Hospital, Yokohama, Kanagawa, Japan;Department of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-kuYokohama, Kanagawa, Japan;Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA;Department of Urology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-kuYokohama, Kanagawa, Japan;

关键词: Ramelteon;    Melatonin;    Nocturia;    Benign prostate hyperplasia;    α-blocker;   

DOI  :  10.1186/1471-2490-13-30

 received in 2013-03-10, accepted in 2013-06-04,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundNocturia is defined as waking one or more times during the night due to the urge to void. Recently, the effectiveness of several sedatives and analgesics for nocturia has been reported. We herein investigated the effects of ramelteon, an antioxidant and sleep inducer, on nocturia unresponsive to α1-blocker monotherapy in males with lower urinary tract symptoms (LUTS) as a pilot study.MethodsSubjects were 19 patients who had LUTS suggestive of benign prostate hyperplasia, received α1-blockers (tamsulosin, silodosin, or naftopidil), and continued to have two or more episodes of nocturia per night before starting ramelteon. Ramelteon at 8 mg once daily for one month was added to the α1-blocker. A self-administered questionnaire including the International Prostate Symptom Score (IPSS), quality of life (QoL) index, Overactive Bladder Symptom Score (OABSS), and Nocturia Quality-of-Life Questionnaire (N-QOL) were assessed before and one month after starting ramelteon.ResultsThe mean score on IPSS question 7 (nocturia) decreased significantly from 2.88 before starting ramelteon to 2.41 one month after starting the medication (P = 0.03). The mean total OABSS decreased significantly from 6.31 to 5.38 (P = 0.03), and the mean for OABSS question 2 (nighttime frequency of nocturia) also significantly decreased from 2.63 to 2.13 (P = 0.01). The mean total N-QOL score did not change significantly. Two patients had dizziness; the remaining patients had no adverse drug-related events.ConclusionsRamelteon in combination with an α1-blocker could be a treatment option for reducing nocturia in men with BPH.

【 授权许可】

CC BY   
© Kawahara et al.; licensee BioMed Central Ltd. 2013