Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

BMC Public Health

Research Article

Mª Teresa Segura¹  María J. Aguilar¹  Francisco J Torres-Espinola¹  Cristina Martínez-Zaldívar¹  Luz García-Valdés¹  Staffan K. Berglund²  Cristina Campoy³  Signe Altmäe³  Jose A. Lorente⁴  M. Carmen López-Sabater⁵  Carmen Padilla⁶  Jesús Florido⁶  Ahmad Agil⁷  Acensión Marcos⁸ 

[1] Centre of Excellence for Paediatric Research EURISTIKOS, Department of Paediatrics, School of Medicine, University of Granada, Avda. De Madrid 11, 18012, Granada, Spain;Centre of Excellence for Paediatric Research EURISTIKOS, Department of Paediatrics, School of Medicine, University of Granada, Avda. De Madrid 11, 18012, Granada, Spain;Department of Clinical Sciences, Pediatrics, Umeå University, 901 85, Umeå, Sweden;Centre of Excellence for Paediatric Research EURISTIKOS, Department of Paediatrics, School of Medicine, University of Granada, Avda. De Madrid 11, 18012, Granada, Spain;Department of Paediatrics, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain;Department of Legal Medicine, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain;Department of Nutrition and Bromatology, University of Barcelona, Joan XXIII 27-31, 08028, Barcelona, Spain;Department of Obstetrics and Gynaecology, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain;Department of Pharmacology, University of Granada, Avda. de la Investigación 11, 18016, Granada, Spain;Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Institute of Food Sciences, José Antonio Novais 10, 28040, Madrid, Spain;

关键词: Pregnancy;    Maternal overweight;    Maternal obesity;    Gestational diabetes;    Offspring;    Fetal nutrition;    Early programming;    Vitamin B12;    Folate;    Iron status;    Glucose metabolism;   

DOI  :  10.1186/s12889-016-2809-3

 received in 2015-09-19, accepted in 2016-02-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMaternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted.MethodsIn an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks (n = 269), 34 weeks (n = 310) and at delivery (n = 310) and the perinatal characteristics including cord blood biomarkers.ResultsObese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight, waist circumference, and placental weight were higher in the obese group, including a significantly increased prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher levels of folate. The latter was seen also in cord blood.ConclusionsWe identified several metabolic alterations in overweight, obese and GD mothers compared to controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in future research regarding the programming of health and disease in children.Trial registrationThe trial was registered at clinicaltrials.gov, identifier (NCT01634464).

【 授权许可】

CC BY   
© Berglund et al. 2016